Protein: MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10)

Gene: MTMR3
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q13615

Gene Ontology (top 5):
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1112460

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

5

18

Small-scale

0.919

High

1112428

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

2

17

High-throughput

0.754

High

170128

AURKA
Aurora kinase A

5

6

High-throughput

0.714

High

729813

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.687

High

919946

PLK1
Serine/threonine-protein kinase PLK1

4

7

High-throughput

0.686

High

966288

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1049269

1433F
14-3-3 protein eta

3

20

High-throughput

0.662

High

1112458

PNO1
RNA-binding protein PNO1

3

0

High-throughput

0.638

High

488219

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

High-throughput

0.628

High

1112437

DJC10
DnaJ homolog subfamily C member 10

2

5

High-throughput

0.628

High

1112429

CUL3
Cullin-3

2

9

High-throughput

0.611

High

1112431

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

10

High-throughput

0.606

High

1112457

EXOS5
Exosome complex component RRP46

2

2

High-throughput

0.606

High

1112446

HDA11
Histone deacetylase 11

3

4

High-throughput

0.604

High

279359

TULP3
Tubby-related protein 3

2

1

High-throughput

0.574

High

1112450

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.574

High

1112463

WRP73
WD repeat-containing protein WRAP73

2

2

High-throughput

0.571

High

641169

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.541

High

269193

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.536

High

335453

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.536

High

839265

MTOR
Serine/threonine-protein kinase mTOR

1

8

Small-scale

0.536

High

854646

RAGP1
Ran GTPase-activating protein 1

1

2

High-throughput

0.536

High

971497

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.536

High

990194

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1102155

ATM
Serine-protein kinase ATM

1

7

High-throughput

0.536

High

1112439

RPTOR
Regulatory-associated protein of mTOR

1

8

Small-scale

0.536

High

1112441

THOC2
THO complex subunit 2

1

9

High-throughput

0.536

High

1112447

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

1

High-throughput

0.536

High

1112452

LST8
Target of rapamycin complex subunit LST8

1

3

Small-scale

0.536

High

1112456

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1112459

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.536

High

1112461

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

1112462

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

1

3

High-throughput

0.536

High

719218

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.513

High

647315

IL10
Interleukin-10

1

1

High-throughput

0.489

High

706121

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

1112436

TLK2
Serine/threonine-protein kinase tousled-like 2

1

7

High-throughput

0.489

High

134027

IPO5
Importin-5

1

2

High-throughput

0.479

High

177214

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

2

High-throughput

0.479

High

315564

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

342860

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

High-throughput

0.479

High

1112432

CEP55
Centrosomal protein of 55 kDa

1

1

High-throughput

0.479

High

1112433

SYNE3
Nesprin-3

1

9

High-throughput

0.479

High

1112434

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1112438

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.479

High

1112444

NU205
Nuclear pore complex protein Nup205

1

2

High-throughput

0.479

High

1112448

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

1112449

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.479

High

586292

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.460

High

231476

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.458

High

1112451

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1112454

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.458

High

1112466

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1112430

EXOS7
Exosome complex component RRP42

1

1

Small-scale

0.457

High

1112445

EXOS8
Exosome complex component RRP43

1

1

Small-scale

0.457

High

400799

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

690983

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

877108

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.445

High

1112465

EXOS1
Exosome complex component CSL4

1

0

Small-scale

0.438

High

551032

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.437

High

1112440

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

1

High-throughput

0.437

High

1112443

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1112435

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1112442

NET5
Netrin-5

1

1

High-throughput

0.407

High

328241

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

1112455

STN1
CST complex subunit STN1

1

0

High-throughput

0.279

Low

1112464

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

1048501

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.249

Low

946995

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

1112453

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025