Protein: UPAR
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

Gene: UPAR, PLAUR
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q03405

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005788 - endoplasmic reticulum lumen
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366484

UROK
Urokinase-type plasminogen activator

6

0

Small-scale

0.895

High

337529

LARG1
Xylosyl- and glucuronyltransferase LARGE1

3

1

High-throughput

0.667

High

582324

ARSA
Arylsulfatase A

3

4

High-throughput

0.667

High

586373

ARSB
Arylsulfatase B

3

4

High-throughput

0.667

High

756544

GALNS
N-acetylgalactosamine-6-sulfatase

3

4

High-throughput

0.667

High

914859

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

3

1

High-throughput

0.667

High

1042628

MA2A1
Alpha-mannosidase 2

3

1

High-throughput

0.667

High

1042630

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

3

1

High-throughput

0.667

High

1042636

ARSK
Arylsulfatase K

3

4

High-throughput

0.667

High

1042644

CHSS1
Chondroitin sulfate synthase 1

3

1

High-throughput

0.667

High

1042649

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

3

1

High-throughput

0.667

High

1042656

PCSK5
Proprotein convertase subtilisin/kexin type 5

3

1

High-throughput

0.667

High

755391

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

3

0

High-throughput

0.638

High

937386

LAMB2
Laminin subunit beta-2

3

0

High-throughput

0.638

High

1042613

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

3

0

High-throughput

0.638

High

1042614

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

3

0

High-throughput

0.638

High

1042618

MELK
Maternal embryonic leucine zipper kinase

3

0

High-throughput

0.638

High

1042625

EXT1
Exostosin-1

3

0

High-throughput

0.638

High

1042626

PKN1
Serine/threonine-protein kinase N1

3

0

High-throughput

0.638

High

1042629

OFUT4
GDP-fucose protein O-fucosyltransferase 4

3

0

High-throughput

0.638

High

1042651

PGLT1
Protein O-glucosyltransferase 1

3

0

High-throughput

0.638

High

1042653

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

3

0

High-throughput

0.638

High

1042655

PXDN
Peroxidasin homolog

3

0

High-throughput

0.638

High

1042661

DHRS4
Dehydrogenase/reductase SDR family member 4

3

0

High-throughput

0.638

High

1042667

MCM9
DNA helicase MCM9

3

0

High-throughput

0.638

High

1042669

DNJB9
DnaJ homolog subfamily B member 9

3

0

High-throughput

0.638

High

1042675

LOXL2
Lysyl oxidase homolog 2

3

0

High-throughput

0.638

High

1042619

MBTP1
Membrane-bound transcription factor site-1 protease

2

1

High-throughput

0.611

High

1042666

EMIL3
EMILIN-3

2

1

High-throughput

0.611

High

885466

MA2A2
Alpha-mannosidase 2x

3

1

High-throughput

0.609

High

907212

SPHM
N-sulphoglucosamine sulphohydrolase

3

4

High-throughput

0.609

High

914841

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

3

1

High-throughput

0.609

High

1042638

CHSS3
Chondroitin sulfate synthase 3

3

1

High-throughput

0.609

High

1042647

LARG2
Xylosyl- and glucuronyltransferase LARGE2

3

1

High-throughput

0.609

High

1042659

DDX11
ATP-dependent DNA helicase DDX11

3

1

High-throughput

0.609

High

463470

LYN
Tyrosine-protein kinase Lyn

2

2

Small-scale

0.601

High

1042662

TX101
Testis-expressed protein 101

1

0

Small-scale

0.586

High

932361

ANAG
Alpha-N-acetylglucosaminidase

2

0

High-throughput

0.585

High

933998

PLTP
Phospholipid transfer protein

2

0

High-throughput

0.585

High

424073

ITB2
Integrin beta-2

2

0

Small-scale

0.559

High

1042671

PCYOX
Prenylcysteine oxidase 1

2

1

High-throughput

0.558

High

1042612

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

Small-scale

0.537

High

611722

BMP7
Bone morphogenetic protein 7

1

1

High-throughput

0.536

High

996915

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.536

High

1042663

CST11
Cystatin-11

1

2

High-throughput

0.536

High

996111

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

658693

JAK1
Tyrosine-protein kinase JAK1

1

4

Small-scale

0.515

High

714610

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

4

Small-scale

0.515

High

593658

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

994907

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.513

High

1034721

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1042658

CTHR1
Collagen triple helix repeat-containing protein 1

1

0

High-throughput

0.513

High

1042664

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1042668

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.513

High

370410

KNG1
Kininogen-1

1

2

Small-scale

0.501

High

47320

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

442298

GELS
Gelsolin

1

0

High-throughput

0.493

High

926956

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1042641

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

760792

BMP8B
Bone morphogenetic protein 8B

1

1

High-throughput

0.489

High

384398

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

539469

ITAM
Integrin alpha-M

1

0

Small-scale

0.480

High

548486

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

Small-scale

0.480

High

1042615

SEPR
Prolyl endopeptidase FAP

1

0

Small-scale

0.480

High

397941

ANGI
Angiogenin

1

0

Small-scale

0.479

High

410786

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

473400

HCK
Tyrosine-protein kinase HCK

1

2

Small-scale

0.479

High

486686

FGR
Tyrosine-protein kinase Fgr

1

2

Small-scale

0.479

High

774304

BASI
Basigin

1

1

High-throughput

0.479

High

1042639

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.479

High

1042652

PCYXL
Prenylcysteine oxidase 1-like

1

1

High-throughput

0.479

High

218082

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

371820

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

477138

5HT1A
5-hydroxytryptamine receptor 1A

1

0

Small-scale

0.458

High

873769

CD151
CD151 antigen

1

0

Small-scale

0.458

High

1035550

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1042621

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

1042622

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1042632

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.458

High

1042648

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

Small-scale

0.458

High

1042650

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1042670

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.458

High

1042624

SURF2
Surfeit locus protein 2

1

0

High-throughput

0.438

High

370188

CYTN
Cystatin-SN

1

2

Small-scale

0.437

High

222266

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

1042660

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.426

High

70006

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

1

High-throughput

0.407

High

219946

XRCC3
DNA repair protein XRCC3

3

0

High-throughput

0.347

High

261716

HUS1
Checkpoint protein HUS1

3

0

High-throughput

0.347

High

908966

NEK4
Serine/threonine-protein kinase Nek4

3

0

High-throughput

0.347

High

1042611

UBE3A
Ubiquitin-protein ligase E3A

3

0

High-throughput

0.347

High

1042616

TBB3
Tubulin beta-3 chain

3

0

High-throughput

0.347

High

1042627

TAZ
Tafazzin

3

0

High-throughput

0.347

High

1042633

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

3

0

High-throughput

0.347

High

1042642

ADCK1
AarF domain-containing protein kinase 1

3

0

High-throughput

0.347

High

1042645

DYR2
Dihydrofolate reductase 2, mitochondrial

3

0

High-throughput

0.347

High

1042646

P3H3
Prolyl 3-hydroxylase 3

3

0

High-throughput

0.347

High

1042657

TATD2
3'-5' RNA nuclease TATDN2

3

0

High-throughput

0.347

High

1042673

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

3

0

High-throughput

0.347

High

1039481

TOP2B
DNA topoisomerase 2-beta

2

0

High-throughput

0.328

High

665086

COT2
COUP transcription factor 2

2

0

High-throughput

0.318

High

771583

HXD13
Homeobox protein Hox-D13

2

0

High-throughput

0.318

High

873727

GSH0
Glutamate--cysteine ligase regulatory subunit

2

0

High-throughput

0.318

High

1042631

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

2

0

High-throughput

0.318

High

1042634

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

2

0

High-throughput

0.318

High

1042640

TRM11
tRNA

2

0

High-throughput

0.318

High

1042672

NOCT
Nocturnin

2

0

High-throughput

0.318

High

762445

PROF2
Profilin-2

1

0

High-throughput

0.282

High

1042617

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.282

High

177537

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.249

Low

612988

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

787636

SPB5
Serpin B5

1

0

Small-scale

0.249

Low

894464

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.249

Low

903062

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.249

Low

1026700

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

0

Small-scale

0.249

Low

1042620

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

1042623

OZF
Zinc finger protein OZF

1

0

High-throughput

0.249

Low

1042635

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

1042637

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1042643

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

0

Small-scale

0.249

Low

1042654

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

Small-scale

0.249

Low

1042665

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

1042674

CDYL
Chromodomain Y-like protein

1

0

High-throughput

0.249

Low

964235

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025