Protein: GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]

Gene: GLUC, GCG
Organism: Homo sapiens
Interactions: 33
UniProt ID: P01275

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377278

GLP1R
Glucagon-like peptide 1 receptor

2

1

Small-scale

0.738

High

377279

GIPR
Gastric inhibitory polypeptide receptor

1

1

Small-scale

0.692

High

377272

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

0

Small-scale

0.665

High

377286

MAEA
E3 ubiquitin-protein transferase MAEA

2

5

High-throughput

0.601

High

377292

RANB9
Ran-binding protein 9

2

2

High-throughput

0.601

High

377281

YPEL5
Protein yippee-like 5

2

0

High-throughput

0.576

High

377299

TCAF1
TRPM8 channel-associated factor 1

2

0

High-throughput

0.576

High

377285

RBP10
Ran-binding protein 10

2

2

High-throughput

0.549

High

377275

IDE
Insulin-degrading enzyme

1

0

Small-scale

0.544

High

183836

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.513

High

342713

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.513

High

377274

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

377282

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

High-throughput

0.513

High

377287

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

377289

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.513

High

207781

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

377290

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

4

High-throughput

0.489

High

377295

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

4

High-throughput

0.489

High

377297

GID8
Glucose-induced degradation protein 8 homolog

1

5

High-throughput

0.489

High

377273

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

377277

ARRB2
Beta-arrestin-2

1

0

Small-scale

0.458

High

377284

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

377276

DPP4
Dipeptidyl peptidase 4

1

1

Small-scale

0.445

High

377283

SEPR
Prolyl endopeptidase FAP

1

1

Small-scale

0.445

High

377280

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.426

High

377298

MKLN1
Muskelin

2

0

High-throughput

0.313

High

328343

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.279

Low

377288

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.279

Low

377291

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

377293

N62CL
Nucleoporin-62 C-terminal-like protein

1

0

High-throughput

0.279

Low

377294

WDR26
WD repeat-containing protein 26

1

0

High-throughput

0.279

Low

377296

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025