Protein: PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]

Gene: PAPS1, PAPSS1
Organism: Homo sapiens
Interactions: 58
UniProt ID: O43252

Gene Ontology (top 5):
GO:0000103 - sulfate assimilation
GO:0001501 - skeletal system development
GO:0004020 - adenylylsulfate kinase activity
GO:0004781 - sulfate adenylyltransferase (ATP) activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211466

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

3

7

High-throughput

0.855

High

185127

FANCG
Fanconi anemia group G protein

2

0

High-throughput

0.602

High

211481

GNL1
Guanine nucleotide-binding protein-like 1

2

0

High-throughput

0.602

High

211489

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

0

High-throughput

0.602

High

211503

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

211482

IMA5
Importin subunit alpha-5

2

1

High-throughput

0.601

High

211508

MCRI2
MAPK regulated corepressor interacting protein 2

2

1

High-throughput

0.601

High

211462

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

211485

KPCE
Protein kinase C epsilon type

2

0

High-throughput

0.547

High

211473

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

211484

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

211490

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

211464

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

211467

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.513

High

211475

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.513

High

211476

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

211486

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.513

High

211495

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

211502

FBLI1
Filamin-binding LIM protein 1

1

0

High-throughput

0.513

High

211513

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

211506

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

1

High-throughput

0.494

High

211472

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

211479

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

211504

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

211505

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

211515

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

211463

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

211471

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

211487

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.458

High

211498

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

211501

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

211509

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

211514

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

142241

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.445

High

211496

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

211516

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

211469

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

211468

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

211474

GLNA
Glutamine synthetase

1

0

High-throughput

0.426

High

211483

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.426

High

211493

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.426

High

211512

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

211477

CAP7
Azurocidin

1

1

High-throughput

0.407

High

211478

CD27
CD27 antigen

1

1

High-throughput

0.407

High

211517

PCDG9
Protocadherin gamma-A9

1

1

High-throughput

0.407

High

211470

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

211494

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

211499

CC116
Coiled-coil domain-containing protein 116

2

0

High-throughput

0.328

High

211507

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

211511

WDCP
WD repeat and coiled-coil-containing protein

2

0

High-throughput

0.328

High

211492

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

1

0

High-throughput

0.279

Low

211500

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

211510

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.279

Low

211480

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

211497

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

211465

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

211488

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

211491

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025