Protein: PCNP
PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)

Gene: PCNP
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q8WW12

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination
GO:0016604 - nuclear body
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1358926

UHRF2
E3 ubiquitin-protein ligase UHRF2

3

0

Small-scale

0.636

High

372688

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

862324

YAP1
Transcriptional coactivator YAP1

2

1

Small-scale

0.584

High

1358933

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

396597

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1209443

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

907507

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.536

High

1127033

RBM39
RNA-binding protein 39

1

1

High-throughput

0.536

High

1291093

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1358924

SPF45
Splicing factor 45

1

1

High-throughput

0.536

High

1358936

SF3B6
Splicing factor 3B subunit 6

1

1

High-throughput

0.536

High

123784

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.513

High

219987

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

286009

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.513

High

333865

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.513

High

471891

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.513

High

574391

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

775223

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

973994

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

974622

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1148628

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.513

High

1149144

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

1204829

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.513

High

1358925

CAR19
Caspase recruitment domain-containing protein 19

1

0

High-throughput

0.513

High

172154

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.493

High

1358922

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

211376

RFOX2
RNA binding protein fox-1 homolog 2

1

1

High-throughput

0.481

High

247396

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

355567

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

386027

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

406432

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

589260

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606940

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

1094594

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.479

High

1096767

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1155589

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

123414

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

129283

MEN1
Menin

1

0

High-throughput

0.458

High

260217

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

401209

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

445988

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

537601

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

558288

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

696047

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714297

PML
Protein PML

1

0

High-throughput

0.458

High

765737

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.458

High

768746

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

791578

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

832756

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

852813

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.458

High

998595

H31
Histone H3.1

1

0

High-throughput

0.458

High

1137891

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1156795

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1196288

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

1226480

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

1276546

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1280366

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1289486

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1325500

FBXW8
F-box/WD repeat-containing protein 8

1

0

High-throughput

0.458

High

1336725

ZN439
Zinc finger protein 439

1

0

High-throughput

0.458

High

1358921

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1358923

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1358927

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1358931

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1358934

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1358935

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1227151

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1150772

SF01
Splicing factor 1

1

0

High-throughput

0.426

High

887051

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

349694

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.279

Low

611255

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.279

Low

961471

OSTN
Osteocrin

1

0

High-throughput

0.279

Low

1136295

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1164487

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.279

Low

1204936

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

1326850

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1358928

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

1358929

F107B
Protein FAM107B

1

0

High-throughput

0.279

Low

1358937

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.279

Low

955421

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.261

Low

346114

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

976452

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1049178

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low

1254820

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1358932

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.249

Low

1155083

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1358930

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025