Protein: IL1B
Interleukin-1 beta (IL-1 beta) (Catabolin)

Gene: IL1B
Organism: Homo sapiens
Interactions: 60
UniProt ID: P01584

Gene Ontology (top 5):
GO:0001660 - fever generation
GO:0002711 - positive regulation of T cell mediated immunity
GO:0005125 - cytokine activity
GO:0005149 - interleukin-1 receptor binding
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378550

CASP1
Caspase-1

6

7

Small-scale

0.940

High

378540

IL1R1
Interleukin-1 receptor type 1

3

12

Small-scale

0.840

High

378549

IL1R2
Interleukin-1 receptor type 2

3

12

Small-scale

0.827

High

378579

IL1AP
Interleukin-1 receptor accessory protein

2

11

Small-scale

0.767

High

378542

SPI1
Transcription factor PU.1

4

3

Small-scale

0.676

High

378541

CEBPB
CCAAT/enhancer-binding protein beta

3

1

Small-scale

0.640

High

378566

CASP8
Caspase-8

1

7

Small-scale

0.618

High

378565

IL18
Interleukin-18

1

0

Small-scale

0.586

High

378533

JUN
Transcription factor Jun

2

4

Small-scale

0.584

High

378545

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

7

Small-scale

0.584

High

378560

IRF8
Interferon regulatory factor 8

2

2

Small-scale

0.584

High

378567

IRF4
Interferon regulatory factor 4

2

2

Small-scale

0.584

High

378553

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.537

High

378575

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

2

Small-scale

0.515

High

378534

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.501

High

378537

LYN
Tyrosine-protein kinase Lyn

1

2

Small-scale

0.501

High

378544

EGR1
Early growth response protein 1

1

1

Small-scale

0.481

High

378531

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

378548

CMA1
Chymase

1

0

Small-scale

0.480

High

125699

STXB3
Syntaxin-binding protein 3

1

1

Small-scale

0.479

High

278202

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.479

High

378539

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

378551

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

378552

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

378557

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

378559

RELB
Transcription factor RelB

1

7

Small-scale

0.479

High

378561

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

378562

REL
Proto-oncogene c-Rel

1

7

Small-scale

0.479

High

378568

STXB2
Syntaxin-binding protein 2

1

1

Small-scale

0.479

High

378572

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

3

Small-scale

0.479

High

378574

PDC6I
Programmed cell death 6-interacting protein

1

1

Small-scale

0.479

High

378576

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

Small-scale

0.479

High

378538

SP1
Transcription factor Sp1

1

0

Small-scale

0.460

High

276878

VPS4B
Vacuolar protein sorting-associated protein 4B

1

0

Small-scale

0.458

High

334138

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

Small-scale

0.458

High

378535

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.458

High

378536

UROM
Uromodulin

1

0

Small-scale

0.458

High

378543

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

Small-scale

0.458

High

378546

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

378547

RAB5A
Ras-related protein Rab-5A

1

0

Small-scale

0.458

High

378554

GSDMD
Gasdermin-D

1

0

Small-scale

0.458

High

378555

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

0

Small-scale

0.458

High

378556

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

378558

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

378564

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

378569

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

378577

CHM4B
Charged multivesicular body protein 4b

1

0

Small-scale

0.458

High

378578

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.458

High

378580

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

Small-scale

0.458

High

378581

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

378584

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.458

High

370869

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.445

High

378571

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

280087

SC22B
Vesicle-trafficking protein SEC22b

1

2

Small-scale

0.437

High

378563

SSRP1
FACT complex subunit SSRP1

1

2

Small-scale

0.437

High

378583

ASC
Apoptosis-associated speck-like protein containing a CARD

1

3

Small-scale

0.428

High

378573

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

378570

TR16L
Tripartite motif-containing protein 16-like protein

1

0

Small-scale

0.264

Low

378582

FBXL2
F-box/LRR-repeat protein 2

1

0

Small-scale

0.261

Low

378532

PPB1
Alkaline phosphatase, placental type

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025