Protein: LYPA1
Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)

Gene: LYPA1, LYPLA1
Organism: Homo sapiens
Interactions: 41
UniProt ID: O75608

Gene Ontology (top 5):
GO:0002084 - protein depalmitoylation
GO:0004620 - phospholipase activity
GO:0004622 - phosphatidylcholine lysophospholipase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

288860

TRI11
E3 ubiquitin-protein ligase TRIM11

2

1

High-throughput

0.628

High

288855

SMBT2
Scm-like with four MBT domains protein 2

2

1

High-throughput

0.606

High

288851

GOGA2
Golgin subfamily A member 2

3

1

High-throughput

0.597

High

288854

TEAD4
Transcriptional enhancer factor TEF-3

2

0

High-throughput

0.585

High

288836

LYPA1
Acyl-protein thioesterase 1

1

2

Small-scale

0.575

High

288843

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

288846

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

287210

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.513

High

288839

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.513

High

288844

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

288845

HXD11
Homeobox protein Hox-D11

1

0

High-throughput

0.513

High

288850

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

288856

ARHGG
Rho guanine nucleotide exchange factor 16

1

0

High-throughput

0.513

High

288858

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

288859

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

288861

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.513

High

288862

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

288868

BEX4
Protein BEX4

1

0

High-throughput

0.513

High

288870

GUC1B
Guanylyl cyclase-activating protein 2

1

0

High-throughput

0.513

High

288871

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

288872

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.513

High

288873

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

288842

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

288848

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

288852

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

288857

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

288869

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

288840

FINC
Fibronectin

1

0

High-throughput

0.458

High

288841

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

288847

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

288853

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

288865

GPCP1
Glycerophosphocholine phosphodiesterase GPCPD1

1

0

Small-scale

0.458

High

261019

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

288838

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

288866

S17A5
Sialin

1

0

High-throughput

0.426

High

288867

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

288849

CATO
Cathepsin O

3

0

High-throughput

0.347

High

288837

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

288864

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

288863

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025