Protein: MED16
Mediator of RNA polymerase II transcription subunit 16 (Global transcriptional regulator SIN4) (Mediator complex subunit 16) (SNF1 suppressor protein 4) (SWI4 suppressor protein 5) (Transcriptional silencing factor 3) (YGP1 expression regulatory protein 1)

Gene: MED16, SIN4
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P32259

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686857

MED5
Mediator of RNA polymerase II transcription subunit 5

6

0

Small-scale

0.896

High

686868

MED7
Mediator of RNA polymerase II transcription subunit 7

8

1

Small-scale

0.746

High

686842

MED8
Mediator of RNA polymerase II transcription subunit 8

7

1

Small-scale

0.741

High

686832

MED18
Mediator of RNA polymerase II transcription subunit 18

9

0

Small-scale

0.720

High

581340

MED14
Mediator of RNA polymerase II transcription subunit 14

9

0

Small-scale

0.716

High

586269

MED15
Mediator of RNA polymerase II transcription subunit 15

9

0

Small-scale

0.716

High

686830

MED17
Mediator of RNA polymerase II transcription subunit 17

8

0

Small-scale

0.714

High

686831

MED22
Mediator of RNA polymerase II transcription subunit 22

4

0

Small-scale

0.658

High

626014

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.654

High

686871

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

High-throughput

0.654

High

686849

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.644

High

686856

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.634

High

686836

MED9
Mediator of RNA polymerase II transcription subunit 9

3

0

Small-scale

0.622

High

686844

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.616

High

686855

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

3

0

High-throughput

0.616

High

686852

TAF1
Transcription initiation factor TFIID subunit 1

2

0

High-throughput

0.595

High

635980

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.585

High

686837

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.585

High

686846

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

High-throughput

0.585

High

686864

TAF12
Transcription initiation factor TFIID subunit 12

2

0

Small-scale

0.585

High

686874

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

686866

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.576

High

686876

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.576

High

365949

HSP82
ATP-dependent molecular chaperone HSP82

2

0

High-throughput

0.559

High

375313

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.559

High

686873

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

419828

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.529

High

587826

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

686870

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.513

High

633022

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.500

High

589543

SFL1
Flocculation suppression protein

1

0

Small-scale

0.493

High

539451

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

High-throughput

0.486

High

686834

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.486

High

686851

GLDS1
Protein GDS1

1

0

High-throughput

0.486

High

686853

MAD3
Spindle assembly checkpoint component MAD3

1

0

High-throughput

0.486

High

686860

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

523351

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

557935

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

561852

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.458

High

661580

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

686829

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

686838

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

686839

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

686843

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

686845

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

686847

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

686861

H3
Histone H3

1

0

High-throughput

0.458

High

686865

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

686872

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

686877

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

686878

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

355389

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

439992

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.426

High

493416

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

510556

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

686863

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

679523

RM09
Large ribosomal subunit protein uL3m

2

0

High-throughput

0.307

High

333364

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.265

Low

686835

CSE1
Importin alpha re-exporter

1

0

High-throughput

0.265

Low

686850

MAD2
Mitotic spindle checkpoint component MAD2

1

0

High-throughput

0.265

Low

686858

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.265

Low

686859

YG32
Uncharacterized protein YGR117C

1

0

High-throughput

0.265

Low

686862

PT191
Mitochondrial protein PET191

1

0

High-throughput

0.265

Low

367834

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

498462

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

686875

HSP42
Heat shock protein 42

1

0

High-throughput

0.261

Low

383007

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405493

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

407793

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

413369

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

470922

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

472073

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

482137

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

645314

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

686833

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

686840

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

686841

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

686848

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

686867

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

686869

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

686854

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024