Protein: HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphohydrolase (EC 3.6.1.31); Histidinol dehydrogenase (HDH) (EC 1.1.1.23)]

Gene: HIS2, HIS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P00815

Gene Ontology (top 5):
GO:0000105 - L-histidine biosynthetic process
GO:0004399 - histidinol dehydrogenase activity
GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 - phosphoribosyl-ATP diphosphatase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366695

HSP72
Heat shock protein SSA2

3

1

High-throughput

0.624

High

366690

PDC1
Pyruvate decarboxylase isozyme 1

3

0

High-throughput

0.616

High

366725

FMP48
Probable serine/threonine-protein kinase FMP48

2

0

High-throughput

0.602

High

366694

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.571

High

366692

TBA3
Tubulin alpha-3 chain

2

0

High-throughput

0.563

High

366696

METK1
S-adenosylmethionine synthase 1

2

0

High-throughput

0.563

High

366714

DHH1
ATP-dependent RNA helicase DHH1

2

0

High-throughput

0.563

High

366719

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

366697

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

366693

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

366700

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

366705

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

366733

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

366687

HSP82
ATP-dependent molecular chaperone HSP82

1

0

Small-scale

0.458

High

366689

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

366698

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

366701

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.458

High

366703

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

366706

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

366710

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

366711

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

366712

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

366716

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

366726

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

366727

COFI
Cofilin

1

0

High-throughput

0.458

High

366707

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

366708

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

364844

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

366686

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

366688

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

366691

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

366699

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

366713

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

366718

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

366721

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

366730

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

High-throughput

0.269

Low

366717

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

366685

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.249

Low

366702

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

366704

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

366709

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

366723

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

366724

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

366728

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

366729

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

366731

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.249

Low

366732

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

366715

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

366720

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low

366722

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025