Protein: HXKA
Hexokinase-1 (EC 2.7.1.1) (Hexokinase PI) (Hexokinase-A)

Gene: HXKA, HXK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 192
UniProt ID: P04806

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity
GO:0005524 - ATP binding
GO:0005536 - D-glucose binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416327

HXKB
Hexokinase-2

3

14

High-throughput

0.836

High

416326

HXKA
Hexokinase-1

3

14

Small-scale

0.821

High

416360

HSC82
ATP-dependent molecular chaperone HSC82

3

7

High-throughput

0.633

High

416387

CDC48
Cell division control protein 48

2

4

High-throughput

0.594

High

416415

TCTP
Translationally-controlled tumor protein homolog

2

2

High-throughput

0.594

High

416398

HS104
Heat shock protein 104

2

5

Small-scale

0.584

High

416349

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.571

High

416476

TRM82
tRNA

1

1

High-throughput

0.515

High

364211

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.500

High

416328

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.500

High

416331

KAPC
cAMP-dependent protein kinase type 3

1

4

High-throughput

0.500

High

416336

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.500

High

416344

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.500

High

416357

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.500

High

416367

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

416368

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.500

High

416371

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.500

High

416374

KC11
Casein kinase I homolog 1

1

6

High-throughput

0.500

High

416375

KC12
Casein kinase I homolog 2

1

4

High-throughput

0.500

High

416379

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.500

High

416393

HRR25
Casein kinase I homolog HRR25

1

2

High-throughput

0.500

High

416396

RAD16
DNA repair protein RAD16

1

3

High-throughput

0.500

High

416397

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.500

High

416399

DBF20
Serine/threonine-protein kinase DBF20

1

4

High-throughput

0.500

High

416400

KNS1
Dual specificity protein kinase KNS1

1

2

High-throughput

0.500

High

416401

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

416403

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.500

High

416404

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.500

High

416405

GYP6
GTPase-activating protein GYP6

1

1

High-throughput

0.500

High

416406

KU70
ATP-dependent DNA helicase II subunit 1

1

1

High-throughput

0.500

High

416407

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.500

High

416417

YPT10
GTP-binding protein YPT10

1

4

High-throughput

0.500

High

416420

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.500

High

416422

IMB2
Importin subunit beta-2

1

1

High-throughput

0.500

High

416423

SHE3
SWI5-dependent HO expression protein 3

1

1

High-throughput

0.500

High

416424

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

4

High-throughput

0.500

High

416426

RCK2
Serine/threonine-protein kinase RCK2

1

4

High-throughput

0.500

High

416433

DUN1
DNA damage response protein kinase DUN1

1

5

High-throughput

0.500

High

416434

MET30
F-box protein MET30

1

2

High-throughput

0.500

High

416437

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

416443

TBP6
Probable 26S proteasome subunit YTA6

1

6

High-throughput

0.500

High

416446

AIR1
Protein AIR1

1

1

High-throughput

0.500

High

416450

SKP2
F-box protein SKP2

1

1

High-throughput

0.500

High

416451

MOB2
CBK1 kinase activator protein MOB2

1

1

High-throughput

0.500

High

416454

TOS3
Serine/threonine-protein kinase TOS3

1

1

High-throughput

0.500

High

416459

PPP5
Serine/threonine-protein phosphatase T

1

6

High-throughput

0.500

High

416463

CWC22
Pre-mRNA-splicing factor CWC22

1

1

High-throughput

0.500

High

416465

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.500

High

416466

SIW14
Inositol diphosphatase SIW14

1

2

High-throughput

0.500

High

416469

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.500

High

416470

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.500

High

416474

TDA1
Serine/threonine-protein kinase TDA1

1

3

High-throughput

0.500

High

416486

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.500

High

416489

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

4

High-throughput

0.500

High

416490

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.500

High

416493

ATG5
Autophagy protein 5

1

2

High-throughput

0.500

High

416497

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

416369

ACE2
Metallothionein expression activator

1

0

High-throughput

0.493

High

416479

KYNU
Kynureninase

1

0

High-throughput

0.493

High

416487

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.493

High

416496

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.481

High

399290

PYRF
Orotidine 5'-phosphate decarboxylase

1

0

High-throughput

0.479

High

416337

CALM
Calmodulin

1

0

High-throughput

0.479

High

416338

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.479

High

416351

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

0

High-throughput

0.479

High

416372

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.479

High

416381

RAD57
DNA repair protein RAD57

1

0

High-throughput

0.479

High

416386

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.479

High

416408

RAD54
DNA repair and recombination protein RAD54

1

0

High-throughput

0.479

High

416409

UBC6
Ubiquitin-conjugating enzyme E2 6

1

0

High-throughput

0.479

High

416421

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.479

High

416429

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.479

High

416444

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

416447

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.479

High

416460

SNT2
E3 ubiquitin-protein ligase SNT2

1

0

High-throughput

0.479

High

416464

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.479

High

416491

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.479

High

416492

WTM1
Transcriptional modulator WTM1

1

0

High-throughput

0.479

High

416495

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.479

High

358925

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.479

High

359103

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

3

High-throughput

0.479

High

359396

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

3

High-throughput

0.479

High

361403

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.479

High

364854

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.479

High

365513

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367637

ENO1
Enolase 1

1

5

High-throughput

0.479

High

367838

ENO2
Enolase 2

1

5

High-throughput

0.479

High

368533

PMG1
Phosphoglycerate mutase 1

1

4

High-throughput

0.479

High

391955

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

409810

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

416334

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

416346

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

416347

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

416348

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

4

High-throughput

0.479

High

416354

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.479

High

416356

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

416359

TAL1
Transaldolase

1

1

High-throughput

0.479

High

416361

STI1
Heat shock protein STI1

1

1

High-throughput

0.479

High

416370

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

416380

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

416384

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

416416

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

416419

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

416435

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

416438

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

416442

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.479

High

416452

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

416462

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

416467

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

416471

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

416472

COFI
Cofilin

1

2

High-throughput

0.479

High

416483

ZEO1
Protein ZEO1

1

1

High-throughput

0.479

High

416494

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

361953

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.458

High

366689

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

366744

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.458

High

368372

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

382770

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

416329

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

416330

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

416332

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

416333

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

416339

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

416340

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

416341

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

416342

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

416345

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

416355

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.458

High

416358

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

416363

THRC
Threonine synthase

1

0

High-throughput

0.458

High

416373

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

416376

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.458

High

416391

AROC
Chorismate synthase ARO2

1

0

High-throughput

0.458

High

416394

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.458

High

416395

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

416402

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

416412

TSA1
Peroxiredoxin TSA1

1

0

Small-scale

0.458

High

416427

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

416430

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

416439

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

416448

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

416453

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.458

High

416455

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

416456

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.458

High

416468

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

416473

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.458

High

416475

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

416478

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

416335

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.457

High

416362

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.457

High

416366

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.457

High

416382

CDC10
Cell division control protein 10

1

2

High-throughput

0.457

High

416389

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

416431

TEM1
Protein TEM1

1

4

High-throughput

0.457

High

416436

SWD1
COMPASS component SWD1

1

3

High-throughput

0.457

High

416449

PFS2
Polyadenylation factor subunit 2

1

1

High-throughput

0.457

High

416457

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.457

High

416477

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

416482

RRP9
Ribosomal RNA-processing protein 9

1

4

High-throughput

0.457

High

416350

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

416352

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

416410

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

416441

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

416461

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

416392

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

416418

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

416484

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

416488

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.437

High

416385

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

416440

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.269

Low

416485

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

416343

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

416353

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

416364

CDC23
Anaphase-promoting complex subunit CDC23

1

0

High-throughput

0.261

Low

416377

SPO13
Meiosis-specific protein SPO13

1

0

High-throughput

0.261

Low

416378

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

416383

YCP2
Uncharacterized protein YCR001W

1

0

High-throughput

0.261

Low

416388

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

416390

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.261

Low

416428

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.261

Low

416445

MNN14
Mannosyltransferase regulator 14

1

0

High-throughput

0.261

Low

416480

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.261

Low

416481

YL352
F-box protein YLR352W

1

0

High-throughput

0.261

Low

416498

HSH49
Protein HSH49

1

0

High-throughput

0.261

Low

416458

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

416365

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

416411

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

416413

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

416414

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

416425

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

416432

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025