Protein: MED17
Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (Suppressor of RNA polymerase B 4)

Gene: MED17, SRB4
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P32569

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001139 - RNA polymerase II complex recruiting activity
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693530

MED8
Mediator of RNA polymerase II transcription subunit 8

17

2

Small-scale

0.987

High

693569

MED7
Mediator of RNA polymerase II transcription subunit 7

13

2

Small-scale

0.978

High

693518

MED18
Mediator of RNA polymerase II transcription subunit 18

23

0

Small-scale

0.939

High

693535

MED6
Mediator of RNA polymerase II transcription subunit 6

20

0

Small-scale

0.938

High

693517

MED22
Mediator of RNA polymerase II transcription subunit 22

21

0

Small-scale

0.938

High

693526

MED20
Mediator of RNA polymerase II transcription subunit 20

18

0

Small-scale

0.935

High

693578

MED11
Mediator of RNA polymerase II transcription subunit 11

15

0

Small-scale

0.934

High

581341

MED14
Mediator of RNA polymerase II transcription subunit 14

12

0

Small-scale

0.925

High

693576

MED4
Mediator of RNA polymerase II transcription subunit 4

10

0

Small-scale

0.921

High

693533

MED31
Mediator of RNA polymerase II transcription subunit 31

6

0

Small-scale

0.889

High

375321

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

0

Small-scale

0.878

High

693516

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.736

High

586273

MED15
Mediator of RNA polymerase II transcription subunit 15

10

0

Small-scale

0.717

High

693523

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.717

High

593047

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.716

High

693571

MED2
Mediator of RNA polymerase II transcription subunit 2

9

0

Small-scale

0.715

High

686830

MED16
Mediator of RNA polymerase II transcription subunit 16

8

0

Small-scale

0.714

High

693554

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.713

High

626015

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.712

High

693545

MED3
Mediator of RNA polymerase II transcription subunit 3

8

0

Small-scale

0.712

High

693555

MED5
Mediator of RNA polymerase II transcription subunit 5

7

0

Small-scale

0.710

High

693574

MED1
Mediator of RNA polymerase II transcription subunit 1

7

0

Small-scale

0.710

High

693538

SSN2
Mediator of RNA polymerase II transcription subunit 13

6

0

Small-scale

0.699

High

693539

SSN3
Meiotic mRNA stability protein kinase SSN3

6

0

Small-scale

0.698

High

381532

GAL4
Regulatory protein GAL4

5

0

Small-scale

0.691

High

693566

MED10
Mediator of RNA polymerase II transcription subunit 10

4

0

Small-scale

0.657

High

557950

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

Small-scale

0.643

High

693527

TAF14
Transcription initiation factor TFIID subunit 14

4

0

Small-scale

0.638

High

693549

T2FB
Transcription initiation factor IIF subunit beta

3

0

Small-scale

0.606

High

693548

T2FA
Transcription initiation factor IIF subunit alpha

3

0

Small-scale

0.597

High

425545

RAD2
DNA repair protein RAD2

2

0

Small-scale

0.593

High

526971

TBP
TATA-box-binding protein

2

0

Small-scale

0.577

High

693525

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

Small-scale

0.577

High

693551

RSC8
Chromatin structure-remodeling complex protein RSC8

2

1

Small-scale

0.576

High

449964

HSP73
Heat shock protein SSA3

2

2

Small-scale

0.571

High

368724

GCN4
General control transcription factor GCN4

2

0

Small-scale

0.559

High

635982

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

Small-scale

0.559

High

493483

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

693537

RPB11
DNA-directed RNA polymerase II subunit RPB11

2

0

Small-scale

0.547

High

693573

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

510649

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.536

High

587828

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.518

High

636010

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.518

High

693560

CAF40
Protein CAF40

1

0

High-throughput

0.518

High

659765

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.486

High

436828

SWI5
Transcriptional factor SWI5

1

0

Small-scale

0.480

High

687670

BTAF1
TATA-binding protein-associated factor MOT1

1

2

Small-scale

0.479

High

693520

SWI3
SWI/SNF complex subunit SWI3

1

1

Small-scale

0.479

High

693544

RAD26
DNA repair and recombination protein RAD26

1

2

Small-scale

0.479

High

693553

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.479

High

419537

RAD1
DNA repair protein RAD1

1

0

Small-scale

0.458

High

420438

RAD10
DNA repair protein RAD10

1

0

Small-scale

0.458

High

452079

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.458

High

577139

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

Small-scale

0.458

High

579780

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

603289

SNF2
Transcription regulatory protein SNF2

1

0

Small-scale

0.458

High

661668

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

693528

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

693532

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

693550

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

0

Small-scale

0.458

High

693556

RT102
Regulator of Ty1 transposition protein 102

1

0

Small-scale

0.458

High

693557

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

Small-scale

0.458

High

693558

SNF12
Transcription regulatory protein SNF12

1

0

Small-scale

0.458

High

693562

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

693563

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

693564

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.458

High

693568

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

Small-scale

0.458

High

693572

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

693577

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

490671

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

693519

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

693536

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

693543

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

355402

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

439998

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.426

High

593122

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

Small-scale

0.426

High

593217

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.426

High

593297

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.426

High

604665

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

Small-scale

0.426

High

655548

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.426

High

693546

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.426

High

693561

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

Small-scale

0.426

High

693570

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.426

High

693529

LHS1
Heat shock protein 70 homolog LHS1

1

3

High-throughput

0.407

High

693531

ARPC1
Actin-related protein 2/3 complex subunit 1

2

0

Small-scale

0.300

High

667807

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.269

Low

693534

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.269

Low

440141

ERG20
Farnesyl pyrophosphate synthase

1

0

Small-scale

0.251

Low

628785

RNA15
mRNA 3'-end-processing protein RNA15

1

0

Small-scale

0.249

Low

689316

ARP2
Actin-related protein 2

1

0

Small-scale

0.249

Low

693521

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

693522

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.249

Low

693547

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.249

Low

693552

ARP3
Actin-related protein 3

1

0

Small-scale

0.249

Low

693559

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

693565

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.249

Low

693567

CORO
Coronin-like protein

1

0

Small-scale

0.249

Low

692474

ZUO1
Zuotin

1

0

High-throughput

0.232

Low

693524

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

693540

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low

693541

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

693542

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

693575

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024