Protein: CHK1
Serine/threonine-protein kinase CHK1 (EC 2.7.11.1) (Checkpoint kinase 1)

Gene: CHK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P38147

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794286

ACT
Actin

2

2

High-throughput

0.798

High

438199

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.691

High

794289

CDC14
Tyrosine-protein phosphatase CDC14

1

5

High-throughput

0.691

High

441355

KAPB
cAMP-dependent protein kinase type 2

1

2

High-throughput

0.665

High

794269

SECU
Securin

3

0

Small-scale

0.652

High

675933

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.646

High

575277

RAD9
DNA repair protein RAD9

4

0

Small-scale

0.644

High

579260

HSC82
ATP-dependent molecular chaperone HSC82

1

15

Small-scale

0.621

High

794263

CHK1
Serine/threonine-protein kinase CHK1

1

18

Small-scale

0.621

High

625957

UBR1
E3 ubiquitin-protein ligase UBR1

2

0

Small-scale

0.596

High

794284

YNX4
Uncharacterized globin-like protein YNL234W

2

0

Small-scale

0.565

High

381080

H2B1
Histone H2B.1

1

4

High-throughput

0.536

High

381497

H2B2
Histone H2B.2

1

4

High-throughput

0.536

High

534254

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.536

High

794287

H3
Histone H3

1

4

High-throughput

0.536

High

444768

SIR2
NAD-dependent histone deacetylase SIR2

1

0

High-throughput

0.513

High

464321

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

794264

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.513

High

794280

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.513

High

794281

PNC1
Nicotinamidase

1

0

High-throughput

0.513

High

794282

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.513

High

794293

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.513

High

692502

GYS2
Glycogen [starch] synthase isoform 2

1

1

High-throughput

0.508

High

757760

SAS3
Histone acetyltransferase SAS3

1

1

Small-scale

0.508

High

794275

LSM1
LSM1-LSM7 complex subunit LSM1

1

1

High-throughput

0.508

High

368339

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.501

High

649487

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.501

High

746724

KPR1
Ribose-phosphate pyrophosphokinase 1

1

5

High-throughput

0.501

High

794274

ELP2
Elongator complex protein 2

1

1

High-throughput

0.501

High

794279

ASNS1
Asparagine synthetase [glutamine-hydrolyzing] 1

1

3

High-throughput

0.501

High

453553

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.500

High

470513

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.500

High

599000

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.500

High

575437

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

3

High-throughput

0.489

High

794276

NET1
Nucleolar protein NET1

1

1

High-throughput

0.489

High

794290

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.489

High

794291

YMZ2
WD repeat-containing protein YMR102C

1

1

High-throughput

0.489

High

794295

GFD1
mRNA transport factor GFD1

1

0

High-throughput

0.486

High

626565

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.480

High

751355

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.480

High

794278

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.480

High

794283

TR112
Multifunctional methyltransferase subunit TRM112

1

0

High-throughput

0.480

High

794294

EMI2
Putative glucokinase-2

1

0

High-throughput

0.480

High

531308

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

794273

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.479

High

644915

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

794272

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

1

High-throughput

0.479

High

794297

H2AZ
Histone H2A.Z

1

2

High-throughput

0.479

High

706884

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

794266

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

794292

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

408569

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

794268

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.457

High

405077

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

523709

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526489

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

544592

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

794267

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

794288

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

1

1

High-throughput

0.445

High

449337

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.438

High

794270

SDS3
Transcriptional regulatory protein SDS3

1

0

High-throughput

0.438

High

794296

SWR1
Helicase SWR1

1

0

High-throughput

0.426

High

794285

YL152
Uncharacterized transporter YLR152C

1

0

High-throughput

0.279

Low

367950

ENO2
Enolase 2

1

0

High-throughput

0.261

Low

794265

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

0

High-throughput

0.261

Low

794271

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

794277

SNX4
Sorting nexin-4

1

0

High-throughput

0.238

Low

64243

YP010
UPF0495 protein YPR010C-A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025