Protein: MED11
Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)

Gene: MED11
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: Q99278

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001097 - TFIIH-class transcription factor complex binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740446

MED17
Mediator of RNA polymerase II transcription subunit 17

15

0

Small-scale

0.934

High

740483

MED22
Mediator of RNA polymerase II transcription subunit 22

9

0

Small-scale

0.927

High

740824

MED18
Mediator of RNA polymerase II transcription subunit 18

8

0

Small-scale

0.915

High

797730

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.884

High

1062904

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.710

High

619457

MED14
Mediator of RNA polymerase II transcription subunit 14

4

0

Small-scale

0.648

High

751224

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.648

High

917298

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

Small-scale

0.628

High

668506

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.616

High

1084342

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

1084758

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

757604

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.576

High

1054362

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.576

High

801171

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

Small-scale

0.559

High

449373

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

Small-scale

0.529

High

825053

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.486

High

836564

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.479

High

416298

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

594667

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

624958

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

733572

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

734508

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.458

High

739501

ZUO1
Zuotin

1

0

High-throughput

0.458

High

763409

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

764184

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

776686

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

781002

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.458

High

804039

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

804605

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.458

High

807866

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

810681

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

820814

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

823243

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.458

High

865820

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

867870

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

867886

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

1084480

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1084804

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1085062

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

1404000

IGO2
mRNA stability protein IGO2

1

0

High-throughput

0.458

High

924796

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

1060860

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.438

High

1062895

RBX1
RING-box protein HRT1

1

0

High-throughput

0.438

High

581920

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

802612

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

820258

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.426

High

826158

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

782601

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.251

Low

416171

SYTC
Threonine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

454186

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

815118

SS120
Protein SSP120

1

0

High-throughput

0.249

Low

849677

EMP47
Protein EMP47

1

0

High-throughput

0.249

Low

1046973

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025