Protein: MET4
Transcriptional activator of sulfur metabolism MET4 (Methionine-requiring protein 4)

Gene: MET4
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P32389

Gene Ontology (top 5):
GO:0000096 - sulfur amino acid metabolic process
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

736382

MET30
F-box protein MET30

11

0

Small-scale

0.726

High

736386

MET28
Transcriptional activator of sulfur metabolism MET28

5

0

Small-scale

0.684

High

601998

CBF1
Centromere-binding protein 1

4

0

Small-scale

0.656

High

736405

MET32
Transcriptional regulator MET32

2

1

Small-scale

0.631

High

509447

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

0

Small-scale

0.623

High

736368

MET4
Transcriptional activator of sulfur metabolism MET4

2

0

High-throughput

0.579

High

736397

MET31
Transcriptional regulator MET31

1

1

Small-scale

0.573

High

526164

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.571

High

736400

NDE1
Nuclear distribution protein nudE homolog 1

2

0

High-throughput

0.570

High

736369

ZUO1
Zuotin

2

0

High-throughput

0.561

High

615008

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.493

High

574782

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

Small-scale

0.480

High

416208

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

736390

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.479

High

736407

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.479

High

736383

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.470

High

736401

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

736406

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

736373

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

736375

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

736377

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

0

High-throughput

0.458

High

736380

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.458

High

736394

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

736396

PVH1
Tyrosine-protein phosphatase YVH1

1

0

High-throughput

0.458

High

736398

TRM82
tRNA

1

0

High-throughput

0.458

High

736399

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

736404

TRMB
tRNA

1

0

High-throughput

0.458

High

736408

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

736409

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

523344

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

736370

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

416094

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

581838

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

736376

SYG
Glycine--tRNA ligase 1, mitochondrial

1

2

High-throughput

0.437

High

736378

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

736379

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.437

High

736384

SIT1
Siderophore iron transporter 1

1

1

High-throughput

0.437

High

736389

LSB3
LAS seventeen-binding protein 3

1

1

High-throughput

0.437

High

736392

SYC
Cysteine--tRNA ligase

1

1

High-throughput

0.437

High

736402

ENB1
Siderophore iron transporter ENB1

1

1

High-throughput

0.437

High

544148

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

624878

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.391

High

600667

SEC2
Rab guanine nucleotide exchange factor SEC2

2

0

High-throughput

0.310

High

736381

END3
Actin cytoskeleton-regulatory complex protein END3

2

0

High-throughput

0.310

High

724281

ZIP1
Synaptonemal complex protein ZIP1

1

0

High-throughput

0.251

Low

736372

CASP
Protein CASP

1

0

High-throughput

0.251

Low

736388

BUD27
Bud site selection protein 27

1

0

High-throughput

0.251

Low

438644

SC160
Protein SCP160

1

0

High-throughput

0.249

Low

452002

TOM70
Mitochondrial import receptor subunit TOM70

1

0

High-throughput

0.249

Low

454158

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

560790

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

619154

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

687570

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

713493

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.249

Low

736371

DOM34
Protein DOM34

1

0

High-throughput

0.249

Low

736387

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.249

Low

736391

VHT1
Vitamin H transporter

1

0

High-throughput

0.249

Low

736393

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.249

Low

736395

MAP1
Methionine aminopeptidase 1

1

0

High-throughput

0.249

Low

736403

AUS1
ATP-dependent permease AUS1

1

0

High-throughput

0.249

Low

736374

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low

736385

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025