Protein: SYLC
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)

Gene: SYLC, CDC60
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P26637

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006429 - leucyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368872

SYMC
Methionine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.618

High

687591

DHH1
ATP-dependent RNA helicase DHH1

2

3

High-throughput

0.601

High

687597

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

3

High-throughput

0.585

High

366643

ARGI
Arginase

2

0

High-throughput

0.576

High

687569

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

687608

RAGAB
GTP-binding protein GTR1

1

2

Small-scale

0.552

High

687609

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

687571

ATC5
Phospholipid-transporting ATPase DNF1

1

0

High-throughput

0.493

High

687579

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.493

High

459038

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

5

High-throughput

0.489

High

687575

SUI1
Eukaryotic translation initiation factor eIF-1

1

2

High-throughput

0.489

High

687617

UTP4
U3 small nucleolar RNA-associated protein 4

1

5

High-throughput

0.489

High

687627

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.481

High

392329

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.479

High

416088

SYTC
Threonine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

416202

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

434876

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

438630

SC160
Protein SCP160

1

1

High-throughput

0.479

High

558607

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

560786

SYQ
Glutamine--tRNA ligase

1

6

High-throughput

0.479

High

578952

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.479

High

581832

SYKC
Lysine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

679432

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

687568

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

687574

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

687576

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

687577

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

687578

EF1G2
Elongation factor 1-gamma 2

1

4

High-throughput

0.479

High

687580

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

687582

SYG
Glycine--tRNA ligase 1, mitochondrial

1

13

High-throughput

0.479

High

687584

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.479

High

687585

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

687586

YHI0
Putative proline--tRNA ligase YHR020W

1

12

High-throughput

0.479

High

687587

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

687598

ARC1
tRNA-aminoacylation cofactor ARC1

1

8

High-throughput

0.479

High

687603

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

687606

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

687610

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

687611

ESP1
Separin

1

2

High-throughput

0.479

High

687612

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

687614

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

687618

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

687623

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.479

High

687619

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

High-throughput

0.470

High

687622

ATPD
ATP synthase subunit delta, mitochondrial

1

1

High-throughput

0.470

High

454154

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

657054

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

671914

RBSK
Ribokinase

1

0

High-throughput

0.458

High

687600

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

687604

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.458

High

687605

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.458

High

394294

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

439267

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.445

High

453451

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.445

High

486419

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.445

High

523221

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

526061

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

544011

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

592056

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

687588

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

687594

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

687596

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

687601

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

433487

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

441744

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

670399

SIS1
Protein SIS1

1

5

High-throughput

0.437

High

687567

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

687573

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

687581

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.437

High

687583

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

687589

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.437

High

687590

SEC31
Protein transport protein SEC31

1

10

High-throughput

0.437

High

687592

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

687599

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.437

High

687616

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

687620

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

687621

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.437

High

358133

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

403382

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

450535

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

678773

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

671500

SWI4
Regulatory protein SWI4

1

0

High-throughput

0.269

Low

687593

DHE5
NADP-specific glutamate dehydrogenase 2

1

0

High-throughput

0.269

Low

687625

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.251

Low

383554

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

504071

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

687570

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

High-throughput

0.249

Low

687572

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

687595

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.249

Low

687602

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.249

Low

687607

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

687613

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

687615

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.249

Low

687624

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

687626

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025