Protein: M4K3
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)

Gene: M4K3, MAP4K3
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q8IVH8

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1217605

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

4

17

High-throughput

0.896

High

1217576

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

2

15

Small-scale

0.768

High

981057

KPCT
Protein kinase C theta type

1

20

Small-scale

0.734

High

924683

GRB2
Growth factor receptor-bound protein 2

5

20

High-throughput

0.715

High

310708

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

4

High-throughput

0.628

High

1101472

ZN423
Zinc finger protein 423

1

2

High-throughput

0.618

High

350320

RASK
GTPase KRas

1

20

High-throughput

0.618

High

385126

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

1018170

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

15

High-throughput

0.618

High

1030337

G3BP1
Ras GTPase-activating protein-binding protein 1

1

9

High-throughput

0.618

High

1082861

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.618

High

1170693

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1217593

G3BP2
Ras GTPase-activating protein-binding protein 2

1

10

High-throughput

0.618

High

1024138

LCP2
Lymphocyte cytosolic protein 2

1

5

Small-scale

0.569

High

1217584

SH3G1
Endophilin-A2

1

20

High-throughput

0.561

High

894759

RAB8A
Ras-related protein Rab-8A

1

8

Small-scale

0.559

High

1217604

LOXL2
Lysyl oxidase homolog 2

2

2

High-throughput

0.558

High

176469

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.553

High

348766

RASN
GTPase NRas

1

20

High-throughput

0.553

High

441327

RU2B
U2 small nuclear ribonucleoprotein B''

1

7

High-throughput

0.553

High

852101

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

9

High-throughput

0.553

High

1217578

CSN5
COP9 signalosome complex subunit 5

1

11

High-throughput

0.541

High

1217586

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

High-throughput

0.541

High

1217590

ITSN2
Intersectin-2

1

9

High-throughput

0.541

High

914871

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.517

High

1071927

PCBP1
Poly(rC)-binding protein 1

1

6

High-throughput

0.515

High

930913

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

20

High-throughput

0.501

High

1217589

STRN4
Striatin-4

1

20

High-throughput

0.501

High

1191846

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.494

High

944662

I13R1
Interleukin-13 receptor subunit alpha-1

1

10

High-throughput

0.489

High

347251

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

409151

K2C8
Keratin, type II cytoskeletal 8

1

4

High-throughput

0.479

High

417344

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

445462

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

557731

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

666135

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

802868

CRKL
Crk-like protein

1

20

High-throughput

0.479

High

806074

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

900199

RL37A
Large ribosomal subunit protein eL43

1

3

High-throughput

0.479

High

904820

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

921896

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

1058239

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.479

High

1168904

LN28B
Protein lin-28 homolog B

1

6

High-throughput

0.479

High

1217577

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1217585

SH3G3
Endophilin-A3

1

20

High-throughput

0.479

High

1217588

GAN
Gigaxonin

1

5

High-throughput

0.479

High

1217591

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1217592

DBNL
Drebrin-like protein

1

15

High-throughput

0.479

High

1217603

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.479

High

1217606

SNX9
Sorting nexin-9

1

6

High-throughput

0.479

High

1217582

FCRL3
Fc receptor-like protein 3

1

3

High-throughput

0.470

High

63838

RTL1
Retrotransposon-like protein 1

1

1

High-throughput

0.437

High

912329

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

High-throughput

0.437

High

947258

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.437

High

947964

RT11
Small ribosomal subunit protein uS11m

1

2

High-throughput

0.437

High

948291

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.437

High

948627

RT09
Small ribosomal subunit protein uS9m

1

1

High-throughput

0.437

High

974908

CAV1
Caveolin-1

1

8

High-throughput

0.437

High

1084086

OCLN
Occludin

1

8

High-throughput

0.437

High

1163009

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

19

High-throughput

0.437

High

1217579

COA7
Cytochrome c oxidase assembly factor 7

1

6

High-throughput

0.437

High

1217580

PTER
Phosphotriesterase-related protein

1

1

High-throughput

0.437

High

1217583

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.437

High

1217598

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.437

High

1217599

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

1217600

NOP16
Nucleolar protein 16

1

1

High-throughput

0.437

High

1217601

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.437

High

1217602

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.437

High

1217587

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.292

High

241035

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.249

Low

846157

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.249

Low

911888

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.249

Low

947090

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.249

Low

947428

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

947604

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.249

Low

948461

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

1217581

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.249

Low

1217594

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.249

Low

1217595

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

1217596

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low

1217597

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low

1217607

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024