Protein: UBP2
Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)

Gene: UBP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: Q01476

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0010636 - positive regulation of mitochondrial fusion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509684

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

20

Small-scale

0.845

High

815539

RSP5
E3 ubiquitin-protein ligase RSP5

7

8

Small-scale

0.742

High

1030550

RUP1
UBA domain-containing protein RUP1

7

0

Small-scale

0.717

High

850334

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

18

High-throughput

0.665

High

822391

HUA1
Proline-rich protein HUA1

3

2

Small-scale

0.663

High

436490

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

20

Small-scale

0.647

High

509919

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

16

Small-scale

0.647

High

815657

LIS1
Nuclear distribution protein PAC1

1

9

High-throughput

0.621

High

792192

GBLP
Small ribosomal subunit protein RACK1

1

8

Small-scale

0.618

High

812867

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

16

Small-scale

0.618

High

524871

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.601

High

545932

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.601

High

1030547

CORO
Coronin-like protein

1

9

High-throughput

0.595

High

679978

CDC48
Cell division control protein 48

2

3

Small-scale

0.584

High

527449

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

757902

UBX1
UBX domain-containing protein 1

1

1

Small-scale

0.536

High

808439

PUR4
Phosphoribosylformylglycinamidine synthase

1

1

High-throughput

0.515

High

1030538

IMA1
Importin subunit alpha

1

4

High-throughput

0.515

High

1030546

IMB1
Importin subunit beta-1

1

2

High-throughput

0.515

High

402089

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.501

High

585723

UBC4
Ubiquitin-conjugating enzyme E2 4

1

7

Small-scale

0.501

High

764198

SPT23
Protein SPT23

1

7

Small-scale

0.501

High

794825

ECM21
Protein ECM21

1

2

Small-scale

0.501

High

822234

SECU
Securin

1

2

Small-scale

0.501

High

1030552

CSR2
Transcription factor CSR2

1

2

Small-scale

0.501

High

921128

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.486

High

1030542

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.486

High

664336

SSD1
Protein SSD1

1

1

High-throughput

0.481

High

649656

KCC2
Calcium/calmodulin-dependent protein kinase II

1

2

High-throughput

0.479

High

707927

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

779317

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

800674

KPR2
Ribose-phosphate pyrophosphokinase 2

1

5

High-throughput

0.479

High

803372

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

4

Small-scale

0.479

High

808886

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

825115

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

2

High-throughput

0.479

High

1030549

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

782944

JNM1
Nuclear migration protein JNM1

1

0

High-throughput

0.460

High

869273

TEA1
TY1 enhancer activator

1

0

High-throughput

0.460

High

1030539

FIN1
Filament protein FIN1

1

0

High-throughput

0.460

High

1030540

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.460

High

834787

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.458

High

1030541

UBX2
UBX domain-containing protein 2

1

0

Small-scale

0.458

High

1030544

MDM30
Mitochondrial distribution and morphology protein 30

1

0

Small-scale

0.458

High

393188

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.445

High

481728

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

510737

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.445

High

579909

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.445

High

671027

SIS1
Protein SIS1

1

7

High-throughput

0.445

High

671688

SCJ1
DnaJ-related protein SCJ1

1

7

High-throughput

0.445

High

676270

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

742195

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

752620

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

816357

HSP7E
Heat shock protein SSC3, mitochondrial

1

11

High-throughput

0.445

High

819533

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

863697

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.445

High

865040

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.445

High

914879

CWC23
Pre-mRNA-splicing factor CWC23

1

8

High-throughput

0.445

High

1030545

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

17

High-throughput

0.445

High

1030548

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

7

High-throughput

0.445

High

1030551

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

673670

USO1
Intracellular protein transport protein USO1

1

7

High-throughput

0.439

High

751871

SLA2
Protein SLA2

1

4

High-throughput

0.439

High

668352

TSR4
20S rRNA accumulation protein 4

1

0

High-throughput

0.438

High

1030543

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

779568

LHS1
Heat shock protein 70 homolog LHS1

1

11

High-throughput

0.407

High

810875

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.407

High

737184

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.265

Low

864576

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

1030553

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.251

Low

797583

FZO1
Mitofusin FZO1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025