Protein: DCP2
m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Protein PSU1) (mRNA-decapping enzyme subunit 2)

Gene: DCP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P53550

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0003682 - chromatin binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

921144

DCP1
mRNA-decapping enzyme subunit 1

12

1

Small-scale

0.981

High

921122

DCP2
m7GpppN-mRNA hydrolase

2

1

Small-scale

0.793

High

816663

EDC3
Enhancer of mRNA-decapping protein 3

16

4

Small-scale

0.764

High

721645

RENT1
ATP-dependent helicase NAM7

10

1

Small-scale

0.751

High

678710

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

8

3

Small-scale

0.749

High

853602

SCD6
Protein SCD6

7

2

Small-scale

0.741

High

812091

DHH1
ATP-dependent RNA helicase DHH1

5

2

Small-scale

0.716

High

645479

XRN1
5'-3' exoribonuclease 1

5

2

Small-scale

0.713

High

864115

LSM1
LSM1-LSM7 complex subunit LSM1

4

2

Small-scale

0.694

High

817249

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.663

High

921126

LSM3
LSM complex subunit LSM3

3

1

High-throughput

0.647

High

796737

TTL
Probable tubulin--tyrosine ligase PBY1

1

0

Small-scale

0.645

High

921129

RPM2
Ribonuclease P protein component, mitochondrial

3

0

Small-scale

0.637

High

776621

DEF1
RNA polymerase II degradation factor 1

3

0

Small-scale

0.630

High

865267

LSM8
LSM2-LSM8 complex subunit LSM8

2

2

High-throughput

0.603

High

806328

KOG1
Target of rapamycin complex 1 subunit KOG1

2

0

High-throughput

0.600

High

722131

XPO1
Exportin-1

2

0

Small-scale

0.598

High

818026

LSM4
LSM complex subunit LSM4

2

0

High-throughput

0.594

High

916976

EDC1
Enhancer of mRNA-decapping protein 1

1

0

Small-scale

0.586

High

709439

HRR25
Casein kinase I homolog HRR25

2

0

Small-scale

0.585

High

438746

SC160
Protein SCP160

2

1

Small-scale

0.584

High

545740

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.576

High

921132

EBS1
Nonsense-mediated mRNA decay factor EBS1

2

0

Small-scale

0.569

High

921138

NMD4
Nonsense-mediated decay protein 4

2

0

Small-scale

0.569

High

921139

MAK21
Ribosome biogenesis protein MAK21

2

0

High-throughput

0.563

High

807909

BFR1
Nuclear segregation protein BFR1

2

0

Small-scale

0.559

High

527299

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

921123

CAF40
Protein CAF40

1

0

High-throughput

0.518

High

542982

CDC24
Cell division control protein 24

1

0

High-throughput

0.513

High

781850

SPO14
Phospholipase D1

1

1

High-throughput

0.508

High

795899

LSM2
LSM complex subunit LSM2

1

1

High-throughput

0.508

High

917807

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.493

High

921141

RLM1
Transcription factor RLM1

1

0

High-throughput

0.493

High

150100

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

0

High-throughput

0.486

High

423595

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.486

High

446240

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.486

High

473523

LEUR
Regulatory protein LEU3

1

0

High-throughput

0.486

High

661181

SPT6
Transcription elongation factor SPT6

1

0

High-throughput

0.486

High

672116

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.486

High

757793

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.486

High

779784

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.486

High

795752

STU1
Protein STU1

1

0

High-throughput

0.486

High

815320

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

0

High-throughput

0.486

High

863305

CTK3
CTD kinase subunit gamma

1

0

High-throughput

0.486

High

921125

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.486

High

921128

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

High-throughput

0.486

High

921137

GRE2
NADPH-dependent methylglyoxal reductase GRE2

1

0

High-throughput

0.486

High

921143

AHC1
Protein AHC1

1

0

High-throughput

0.486

High

743409

TOR2
Serine/threonine-protein kinase TOR2

1

3

High-throughput

0.481

High

762855

TOR1
Serine/threonine-protein kinase TOR1

1

3

High-throughput

0.481

High

921133

STE20
Serine/threonine-protein kinase STE20

1

0

Small-scale

0.480

High

393105

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

453186

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

2

High-throughput

0.464

High

403600

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

419472

H2A1
Histone H2A.1

1

0

Small-scale

0.458

High

575980

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

Small-scale

0.458

High

585643

STI1
Heat shock protein STI1

1

0

Small-scale

0.458

High

590686

HSP26
Heat shock protein 26

1

0

Small-scale

0.458

High

664325

SSD1
Protein SSD1

1

0

Small-scale

0.458

High

674746

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.458

High

679918

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

707773

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

779085

EF1G2
Elongation factor 1-gamma 2

1

0

Small-scale

0.458

High

779301

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.458

High

779958

DOA1
Protein DOA1

1

0

Small-scale

0.458

High

824925

TM108
Protein TMA108

1

0

High-throughput

0.458

High

826706

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

850122

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

918412

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

921124

NST1
Stress response protein NST1

1

0

Small-scale

0.458

High

921130

NOG1
Nucleolar GTP-binding protein 1

1

0

Small-scale

0.458

High

921134

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

921136

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

921140

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

524699

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

452943

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

453714

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

912419

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

921135

NEW1
[NU+] prion formation protein 1

1

0

High-throughput

0.426

High

679055

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.265

Low

780543

MGR3L
Protein MRG3-like

1

0

High-throughput

0.265

Low

792663

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.265

Low

826987

VLD1
Vacuole localized DSC protein 1

1

0

High-throughput

0.265

Low

827017

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.265

Low

914986

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.265

Low

921142

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.265

Low

921131

TRS31
Trafficking protein particle complex subunit 31

1

0

High-throughput

0.251

Low

758190

ZRT3
Zinc-regulated transporter 3

1

0

High-throughput

0.249

Low

793623

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

812522

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

835946

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.249

Low

921127

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

865302

YJZ3
Putative uncharacterized protein YJR023C

1

0

High-throughput

0.238

Low

810861

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025