Protein: HOT1
High-osmolarity-induced transcription protein 1

Gene: HOT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: Q03213

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0016251 - RNA polymerase II general transcription initiation factor activity
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586011

CSK21
Casein kinase II subunit alpha

5

1

Small-scale

0.726

High

737937

HOG1
Mitogen-activated protein kinase HOG1

5

0

Small-scale

0.694

High

623005

CSK22
Casein kinase II subunit alpha'

4

1

Small-scale

0.691

High

807780

CSK2C
Casein kinase II subunit beta'

5

1

High-throughput

0.656

High

851011

CSK2B
Casein kinase II subunit beta

4

1

High-throughput

0.636

High

670328

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.513

High

739909

RPD3
Histone deacetylase RPD3

1

0

Small-scale

0.493

High

754182

MSN2
Zinc finger protein MSN2

1

1

Small-scale

0.481

High

754239

MSN4
Zinc finger protein MSN4

1

1

Small-scale

0.481

High

777103

BDF1
Bromodomain-containing factor 1

1

1

High-throughput

0.481

High

692613

NSR1
Nuclear localization sequence-binding protein

1

1

Small-scale

0.479

High

818696

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

Small-scale

0.479

High

834724

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

Small-scale

0.479

High

836686

YRB1
Ran-specific GTPase-activating protein 1

1

1

Small-scale

0.479

High

1031035

NOP3
Serine/arginine

1

1

Small-scale

0.479

High

1041920

HOT1
High-osmolarity-induced transcription protein 1

1

1

Small-scale

0.479

High

1041924

YRA1
RNA annealing protein YRA1

1

1

Small-scale

0.479

High

750763

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

793905

SMP1
Transcription factor SMP1

1

0

Small-scale

0.460

High

403637

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

561519

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

626535

AP1
AP-1-like transcription factor YAP1

1

0

Small-scale

0.458

High

632285

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.458

High

632821

DBP5
ATP-dependent RNA helicase DBP5

1

0

Small-scale

0.458

High

694631

SPT5
Transcription elongation factor SPT5

1

0

Small-scale

0.458

High

708002

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

776638

DEF1
RNA polymerase II degradation factor 1

1

0

Small-scale

0.458

High

812164

IFH1
Protein IFH1

1

0

High-throughput

0.458

High

919429

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.458

High

926003

SUB1
RNA polymerase II transcriptional coactivator SUB1

1

0

Small-scale

0.458

High

1028602

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

Small-scale

0.458

High

1041922

PBP4
Protein PBP4

1

0

Small-scale

0.458

High

1041923

SUB2
ATP-dependent RNA helicase SUB2

1

0

Small-scale

0.458

High

524958

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

546044

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

577338

NSP1
Nucleoporin NSP1

1

1

Small-scale

0.437

High

738504

NUP2
Nucleoporin NUP2

1

2

Small-scale

0.437

High

1041925

VAM3
Syntaxin VAM3

1

0

High-throughput

0.251

Low

613785

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low

805780

YHT1
PH domain-containing protein YHR131C

1

0

High-throughput

0.249

Low

824531

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

1041921

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025