Protein: RPA49
DNA-directed RNA polymerase I subunit RPA49 (A49) (DNA-directed RNA polymerase I 49 kDa polypeptide)

Gene: RPA49
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: Q01080

Gene Ontology (top 5):
GO:0001188 - RNA polymerase I preinitiation complex assembly
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534297

RPA1
DNA-directed RNA polymerase I subunit RPA190

9

3

Small-scale

0.968

High

644972

RPA2
DNA-directed RNA polymerase I subunit RPA135

9

5

Small-scale

0.966

High

864034

RPA34
DNA-directed RNA polymerase I subunit RPA34

8

0

Small-scale

0.911

High

739548

RPA12
DNA-directed RNA polymerase I subunit RPA12

3

3

Small-scale

0.830

High

1028596

RPA49
DNA-directed RNA polymerase I subunit RPA49

3

0

High-throughput

0.796

High

858242

RPA43
DNA-directed RNA polymerase I subunit RPA43

8

1

Small-scale

0.745

High

459146

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

6

3

High-throughput

0.735

High

632201

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

1

High-throughput

0.694

High

632282

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

1

High-throughput

0.694

High

1028623

NOP58
Nucleolar protein 58

3

3

High-throughput

0.657

High

632365

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

1

High-throughput

0.601

High

645082

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.601

High

700037

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

2

High-throughput

0.601

High

864311

NET1
Nucleolar protein NET1

2

1

High-throughput

0.601

High

924172

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

2

Small-scale

0.601

High

694619

SPT5
Transcription elongation factor SPT5

2

1

Small-scale

0.595

High

1028610

RRP45
Exosome complex component RRP45

2

0

High-throughput

0.585

High

893389

RPA14
DNA-directed RNA polymerase I subunit RPA14

2

0

High-throughput

0.576

High

1026799

CDC14
Tyrosine-protein phosphatase CDC14

2

0

High-throughput

0.576

High

780576

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

1

Small-scale

0.575

High

826749

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

545926

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

1025158

SEN1
Helicase SEN1

2

0

Small-scale

0.547

High

547820

NHP6A
Non-histone chromosomal protein 6A

1

1

High-throughput

0.541

High

722175

XPO1
Exportin-1

1

2

High-throughput

0.536

High

1028597

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

564670

STE12
Protein STE12

1

0

High-throughput

0.518

High

627865

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

2

High-throughput

0.515

High

656990

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.515

High

1028612

PDP3
NuA3 HAT complex component PDP3

1

1

High-throughput

0.515

High

1028621

NSI1
RNA polymerase I termination factor

1

1

High-throughput

0.515

High

782413

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.513

High

917454

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

671023

SIS1
Protein SIS1

1

0

High-throughput

0.493

High

748147

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.493

High

518108

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

381213

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

382283

H4
Histone H4

1

1

High-throughput

0.479

High

444790

SIR2
NAD-dependent histone deacetylase SIR2

1

2

High-throughput

0.479

High

512593

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

594515

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

677526

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

751463

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.479

High

792191

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

823020

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.479

High

823725

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

826054

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

844577

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

963652

H3
Histone H3

1

1

High-throughput

0.479

High

1028599

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.479

High

1028603

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

1028607

POB3
FACT complex subunit POB3

1

1

High-throughput

0.479

High

1028608

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.479

High

1028609

HRQ1
ATP-dependent helicase HRQ1

1

1

Small-scale

0.479

High

1028619

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.479

High

1028622

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

149902

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

419839

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

435291

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436110

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

436489

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

442061

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

672932

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674777

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

679975

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

689606

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

707920

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735113

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

745841

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

757901

UBX1
UBX domain-containing protein 1

1

0

Small-scale

0.458

High

795965

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

865704

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

920931

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

1028600

RNT1
Ribonuclease 3

1

0

Small-scale

0.458

High

1028601

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

1028602

HOT1
High-osmolarity-induced transcription protein 1

1

0

Small-scale

0.458

High

1028605

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

1028611

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1028613

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

1028615

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

1028616

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1028618

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1028620

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

819525

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

504366

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

778482

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

804381

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

924701

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.426

High

1028604

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.426

High

558836

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.305

High

849834

BUD27
Bud site selection protein 27

2

0

Small-scale

0.305

High

657118

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.269

Low

815427

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.269

Low

827020

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.269

Low

383844

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410285

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433796

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

455210

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503187

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

513160

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514779

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

579907

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

617844

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.249

Low

747524

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753529

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

780052

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

802327

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

812570

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

874471

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

917970

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.249

Low

1025004

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

1028598

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1028606

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

1028614

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

1028617

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025