Protein: TBP
TATA-box-binding protein (TATA sequence-binding protein) (TBP) (TATA-binding factor) (TATA-box factor) (Transcription factor D) (Transcription initiation factor TFIID TBP subunit)

Gene: TBP, SPT15
Organism: Saccharomyces cerevisiae S288C
Interactions: 191
UniProt ID: P13393

Gene Ontology (top 5):
GO:0000126 - transcription factor TFIIIB complex
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001016 - RNA polymerase III transcription regulatory region sequence-specific DNA binding
GO:0001092 - TFIIA-class transcription factor complex binding
GO:0001179 - RNA polymerase I general transcription initiation factor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

561493

TAF1
Transcription initiation factor TFIID subunit 1

32

8

Small-scale

0.993

High

561432

BTAF1
TATA-binding protein-associated factor MOT1

18

6

Small-scale

0.988

High

561446

TOA1
Transcription initiation factor IIA large subunit

17

10

Small-scale

0.985

High

561430

TF3B
Transcription factor IIIB 70 kDa subunit

14

13

Small-scale

0.983

High

561447

T2AG
Transcription initiation factor IIA subunit 2

15

4

Small-scale

0.983

High

561429

TF2B
Transcription initiation factor IIB

12

12

Small-scale

0.977

High

561526

TAF11
Transcription initiation factor TFIID subunit 11

11

2

Small-scale

0.972

High

561499

TAF4
Transcription initiation factor TFIID subunit 4

8

5

Small-scale

0.964

High

449436

SPT3
SAGA complex subunit SPT3

6

3

Small-scale

0.938

High

548812

TAF13
Transcription initiation factor TFIID subunit 13

6

3

Small-scale

0.931

High

561556

NCB2
Negative cofactor 2 complex subunit beta

5

4

Small-scale

0.912

High

561479

NCB1
Negative cofactor 2 complex subunit alpha

5

2

Small-scale

0.909

High

561494

TFC5
Transcription factor TFIIIB component B''

4

2

Small-scale

0.896

High

561404

TBP
TATA-box-binding protein

3

4

Small-scale

0.858

High

561506

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

3

0

Small-scale

0.827

High

561467

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

18

9

Small-scale

0.763

High

561522

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

12

2

Small-scale

0.758

High

561502

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

10

6

Small-scale

0.753

High

561544

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

9

6

Small-scale

0.748

High

561421

TAF2
Transcription initiation factor TFIID subunit 2

8

2

Small-scale

0.743

High

561460

TAF14
Transcription initiation factor TFIID subunit 14

7

2

Small-scale

0.739

High

408387

GAL4
Regulatory protein GAL4

8

0

Small-scale

0.722

High

561533

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

6

3

Small-scale

0.719

High

561503

IMB5
Importin subunit beta-5

7

0

Small-scale

0.714

High

561532

TAF7
Transcription initiation factor TFIID subunit 7

5

5

Small-scale

0.706

High

561437

NGG1
SAGA complex subunit NGG1

4

1

Small-scale

0.696

High

561475

SPT8
SAGA complex subunit SPT8

5

0

Small-scale

0.688

High

561513

ADA2
SAGA complex subunit ADA2

4

3

Small-scale

0.681

High

561459

SPT7
SAGA complex subunit SPT7

4

11

Small-scale

0.676

High

561511

PRS8
26S proteasome regulatory subunit 8 homolog

3

5

Small-scale

0.672

High

561407

HSC82
ATP-dependent molecular chaperone HSC82

3

1

High-throughput

0.650

High

401851

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

4

Small-scale

0.646

High

561489

T2FB
Transcription initiation factor IIF subunit beta

1

1

Small-scale

0.646

High

395217

GCN4
General control transcription factor GCN4

3

0

Small-scale

0.641

High

561408

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

3

Small-scale

0.633

High

561448

RRN6
RNA polymerase I-specific transcription initiation factor RRN6

3

0

Small-scale

0.630

High

154298

MBF1
Multiprotein-bridging factor 1

2

2

Small-scale

0.629

High

561549

TAF3
Transcription initiation factor TFIID subunit 3

3

0

Small-scale

0.622

High

561530

RRN11
RNA polymerase I-specific transcription initiation factor RRN11

3

0

Small-scale

0.619

High

561463

BDF1
Bromodomain-containing factor 1

2

10

Small-scale

0.611

High

561500

SPT20
SAGA complex subunit SPT20

3

0

Small-scale

0.606

High

454382

PHO4
Phosphate system positive regulatory protein PHO4

2

0

Small-scale

0.603

High

561433

IMB3
Importin subunit beta-3

2

1

Small-scale

0.595

High

561534

IMB1
Importin subunit beta-1

2

1

Small-scale

0.595

High

561523

RUVB1
RuvB-like protein 1

1

5

Small-scale

0.589

High

561551

RUVB2
RuvB-like protein 2

1

5

Small-scale

0.589

High

561453

PRS6A
26S proteasome regulatory subunit 6A

2

4

High-throughput

0.588

High

561545

HFI1
SAGA complex subunit HFI1

2

0

Small-scale

0.585

High

561442

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.585

High

561521

TAF8
Transcription initiation factor TFIID subunit 8

2

0

Small-scale

0.585

High

561454

PRS7
26S proteasome regulatory subunit 7 homolog

2

5

Small-scale

0.585

High

561419

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

4

High-throughput

0.584

High

561435

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.584

High

561476

CSK2C
Casein kinase II subunit beta'

2

1

Small-scale

0.584

High

550020

RAP1
DNA-binding protein RAP1

2

0

Small-scale

0.577

High

561441

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.577

High

561457

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

Small-scale

0.576

High

561524

HMO1
High mobility group protein 1

1

1

Small-scale

0.573

High

380939

H2B1
Histone H2B.1

2

1

High-throughput

0.571

High

419572

H2A2
Histone H2A.2

2

1

High-throughput

0.571

High

488911

SWI6
Regulatory protein SWI6

2

2

High-throughput

0.571

High

561512

RSC4
Chromatin structure-remodeling complex subunit RSC4

2

13

High-throughput

0.571

High

561520

GCN5
Histone acetyltransferase GCN5

2

5

High-throughput

0.571

High

561555

H2AZ
Histone H2A.Z

2

2

Small-scale

0.571

High

561486

RRN7
RNA polymerase I-specific transcription initiation factor RRN7

2

0

Small-scale

0.569

High

561525

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.563

High

561413

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.561

High

561491

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.561

High

561510

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

Small-scale

0.561

High

561424

RPC4
DNA-directed RNA polymerase III subunit RPC4

2

0

High-throughput

0.559

High

561514

STD1
Protein STD1

1

0

Small-scale

0.549

High

561436

ASF1
Histone chaperone ASF1

2

0

Small-scale

0.547

High

561541

RSC58
Chromatin structure-remodeling complex protein RSC58

2

0

High-throughput

0.547

High

561469

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

Small-scale

0.545

High

561445

RAD23
UV excision repair protein RAD23

1

0

Small-scale

0.537

High

438121

NOT2
General negative regulator of transcription subunit 2

1

1

Small-scale

0.515

High

561422

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.515

High

561554

NOT5
General negative regulator of transcription subunit 5

1

1

Small-scale

0.515

High

381834

H4
Histone H4

1

0

High-throughput

0.513

High

452705

ADR1
Regulatory protein ADR1

1

0

Small-scale

0.512

High

454330

PHO2
Regulatory protein PHO2

1

2

Small-scale

0.501

High

561406

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.501

High

561484

IST3
U2 snRNP component IST3

1

0

High-throughput

0.486

High

381381

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

392125

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

402179

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.479

High

419341

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

438245

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.479

High

458995

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.479

High

561415

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.479

High

561417

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

561443

STH1
Nuclear protein STH1/NPS1

1

3

High-throughput

0.479

High

561450

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

561451

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

High-throughput

0.479

High

561462

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.479

High

561470

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.479

High

561482

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

561490

RSC8
Chromatin structure-remodeling complex protein RSC8

1

3

High-throughput

0.479

High

561504

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

14

High-throughput

0.479

High

561528

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.479

High

561537

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

10

High-throughput

0.479

High

561409

EF3A
Elongation factor 3A

1

1

High-throughput

0.470

High

561414

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.460

High

561539

CDC73
Cell division control protein 73

1

0

Small-scale

0.460

High

448275

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

513320

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

561412

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.458

High

561425

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.458

High

561426

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.458

High

561427

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.458

High

561431

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

561434

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.458

High

561444

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.458

High

561452

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

561461

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

561464

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

561468

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

561473

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

High-throughput

0.458

High

561474

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

561478

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

561483

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.458

High

561485

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

561492

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.458

High

561497

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

561507

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

561515

ELP4
Elongator complex protein 4

1

0

High-throughput

0.458

High

561517

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

561519

HOT1
High-osmolarity-induced transcription protein 1

1

0

High-throughput

0.458

High

561527

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

561535

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.458

High

561536

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

561538

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

561542

SGO1
Shugoshin

1

0

High-throughput

0.458

High

561546

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

561547

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

561548

MDY2
Ubiquitin-like protein MDY2

1

0

High-throughput

0.458

High

561550

ARP7
Actin-related protein 7

1

0

High-throughput

0.458

High

561553

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

448121

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.445

High

543647

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

561423

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

561455

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

561456

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.445

High

561465

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

561480

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

561509

H3
Histone H3

1

2

High-throughput

0.445

High

561531

RCO1
Transcriptional regulatory protein RCO1

1

3

High-throughput

0.445

High

386543

TBB
Tubulin beta chain

1

1

High-throughput

0.437

High

432792

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

518184

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.437

High

561466

MAK5
ATP-dependent RNA helicase MAK5

1

3

High-throughput

0.437

High

561501

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

561505

ASCC3
RQC trigger complex helicase SLH1

1

2

High-throughput

0.437

High

561516

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

1

Small-scale

0.437

High

403329

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

525787

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

561418

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

561439

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

561471

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

561481

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

561498

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

561508

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

561552

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.426

High

433135

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.407

High

561495

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.407

High

561416

VPS1
Vacuolar protein sorting-associated protein 1

2

0

High-throughput

0.324

High

561410

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

2

0

High-throughput

0.307

High

561411

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.269

Low

561472

BRL1
Nucleus export protein BRL1

1

0

High-throughput

0.269

Low

561496

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.269

Low

561540

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.269

Low

561477

BFR1
Nuclear segregation protein BFR1

1

0

Small-scale

0.261

Low

430761

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.249

Low

452469

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.249

Low

511127

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511727

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

531222

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.249

Low

561428

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.249

Low

561438

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.249

Low

561440

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

561449

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.249

Low

561458

WHI3
Protein WHI3

1

0

High-throughput

0.249

Low

561487

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.249

Low

561488

BNI1
Protein BNI1

1

0

High-throughput

0.249

Low

561518

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.249

Low

561529

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

453389

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

561405

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.232

Low

561420

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

561543

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025