Protein: CHFR
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)

Gene: CHFR
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q96EP1

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919820

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.964

High

849404

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.947

High

1290116

CHFR
E3 ubiquitin-protein ligase CHFR

4

19

Small-scale

0.882

High

1282325

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.861

High

1290120

UB2E2
Ubiquitin-conjugating enzyme E2 E2

3

20

High-throughput

0.861

High

895874

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

861884

PLK1
Serine/threonine-protein kinase PLK1

3

3

Small-scale

0.834

High

1055153

HLTF
Helicase-like transcription factor

2

11

Small-scale

0.819

High

1238397

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

0

High-throughput

0.816

High

896515

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.800

High

160704

AURKA
Aurora kinase A

2

6

Small-scale

0.754

High

455754

PARP1
Poly [ADP-ribose] polymerase 1

7

14

Small-scale

0.743

High

851866

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1284870

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1290117

RN125
E3 ubiquitin-protein ligase RNF125

1

16

High-throughput

0.698

High

1290127

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1054041

GRB14
Growth factor receptor-bound protein 14

1

4

Small-scale

0.648

High

930349

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.647

High

681978

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.618

High

960319

CDK5
Cyclin-dependent kinase 5

1

5

Small-scale

0.618

High

1290119

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.586

High

1273786

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

12

Small-scale

0.584

High

1031702

GRB10
Growth factor receptor-bound protein 10

1

3

Small-scale

0.579

High

1038622

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.578

High

1289396

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.578

High

847054

SMCA4
Transcription activator BRG1

1

12

Small-scale

0.561

High

1017206

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.561

High

1270373

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.561

High

1290118

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.561

High

644126

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.541

High

1290123

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.541

High

1290124

RBX2
RING-box protein 2

1

2

High-throughput

0.541

High

1290126

CBLC
E3 ubiquitin-protein ligase CBL-C

1

2

High-throughput

0.541

High

668900

PML
Protein PML

1

15

Small-scale

0.501

High

517402

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

741080

ZEB1
Zinc finger E-box-binding homeobox 1

1

12

Small-scale

0.479

High

832640

MCM2
DNA replication licensing factor MCM2

1

3

Small-scale

0.479

High

834815

RBP2
E3 SUMO-protein ligase RanBP2

1

5

Small-scale

0.479

High

978851

TF65
Transcription factor p65

1

2

Small-scale

0.479

High

992696

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

Small-scale

0.479

High

1017421

CDC20
Cell division cycle protein 20 homolog

1

9

Small-scale

0.479

High

1029300

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

Small-scale

0.479

High

1042257

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1059552

KIF22
Kinesin-like protein KIF22

1

5

Small-scale

0.479

High

1203225

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

13

Small-scale

0.479

High

1290122

RN126
E3 ubiquitin-protein ligase RNF126

1

1

Small-scale

0.479

High

1290121

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

244770

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.457

High

532591

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.457

High

750779

ITAE
Integrin alpha-E

1

1

High-throughput

0.457

High

443720

VIME
Vimentin

1

12

Small-scale

0.437

High

301492

WDR47
WD repeat-containing protein 47

1

11

High-throughput

0.417

High

1290125

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

High-throughput

0.417

High

1191831

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.328

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024