HitPredict

Interactor 1: DLK1 (P80370)
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]
Gene: DLK1

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 383 Hs			1 861
+	Hs
		1010090 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		861562 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		1010102 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		WWP1_HUMAN (355-855): 1.14e-168: 514: 18.51
+	Hs
		857533 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		857371 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		857554 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		WWP1_HUMAN (355-855): 1.14e-168: 514: 18.51
+	Hs
		1008021 JAG1_HUMAN (114-347): 7.46e-17: 84.4: 15.75		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		857539 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		NED4L_HUMAN (374-853): 5.34e-166: 509: 19.11
+	Hs
		132372 NOTC3_HUMAN (22-244): 1.95e-17: 86.7: 31.37		WWP2_HUMAN (355-855): 2.68e-169: 514: 18.43
+	Dm
		263208 TENM_DROME (207-350): 2.04e-15: 80.2: 12.50		NEDD4_DROME (372-852): 1e-169: 520: 19.36
+	Mm
		1032088 NOTC1_MOUSE (7-312): 1.23e-12: 71.7: 16.99		ITCH_MOUSE (337-855): 1.03e-173: 526: 18.22
+	Dm
		451922 NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77		NEDD4_DROME (372-852): 1e-169: 520: 19.36
+	Hs
		861657 FAT4_HUMAN (57-157): 5.13e-11: 66.7: 23.76		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		861610 FAT1_HUMAN (10-60): 1.58e-09: 62.1: 16.07		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Dm
		451975 NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77		SUDX_DROME (360-855): 4.52e-165: 506: 18.18
+	Hs
		317575 SLIT2_HUMAN (209-331): 1.8e-09: 61.7: 14.29		HUWE1_HUMAN (327-854): 2.82e-151: 494: 19.37
+	Dm
		263321 TENM_DROME (207-350): 2.04e-15: 80.2: 12.50		Q9W325_DROME (440-855): 4.1e-146: 439: 19.07
+	Hs
		1010060 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		UBE3B_HUMAN (533-845): 4.78e-18: 91.7: 28.85
+	Hs
		207807 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		ZZEF1_HUMAN (233-369): 8.74e-18: 91.3: 34.06