HitPredict

Interactor 1: DNJC3 (Q13217)
DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
Gene: DNAJC3

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1620
+	Hs
		1348102 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		445848 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		507978 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411373 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435627 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		411441 TTC13_HUMAN (34-337): 1.83e-49: 183: 21.36		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435695 TTC13_HUMAN (34-337): 1.83e-49: 183: 21.36		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		609403 TMTC1_HUMAN (3-364): 7.42e-38: 150: 14.09		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		609590 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		435780 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		435789 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		1028052 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		385407 DNJC7_HUMAN (31-503): 8.06e-69: 230: 26.05		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		385615 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		1081626 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		384341 CDC27_HUMAN (130-487): 4.57e-18: 89.8: 11.83		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		174540 OGT1_HUMAN (13-134): 3.34e-16: 84: 18.03		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384359 STIP1_HUMAN (24-460): 7.31e-16: 82: 10.91		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		385317 TTC28_HUMAN (17-331): 5.45e-15: 80.4: 13.55		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	At
		1352324 TTL3_ARATH (13-183): 5.67e-22: 101: 14.75		BRL2_ARATH (744-1005): 1.43e-19: 98: 7.44