HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: NAV3 (Q8IVL0)
Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)
Gene: NAV3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007026 - negative regulation of microtubule depolymerization GO:0008017 - microtubule binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2843 Hs			1 2385
+	Hs
		626189 APC_HUMAN (1-2843): 0: 1316: 100.00		NAV2_HUMAN (1-2385): 0: 815: 47.78
+	Hs
		626201 APC_HUMAN (1-2843): 0: 1316: 100.00		NAV1_HUMAN (507-2385): 3.89e-175: 590: 37.38
+	Hs
		597964 APC_HUMAN (1-2843): 0: 1316: 100.00		FLNA_HUMAN (56-1958): 3.04e-130: 461: 10.79
+	Hs
		521470 APC_HUMAN (1-2843): 0: 1316: 100.00		ACTN1_HUMAN (57-429): 8.72e-90: 316: 17.95
+	Hs
		626099 APC_HUMAN (1-2843): 0: 1316: 100.00		SPTB2_HUMAN (35-310): 4.94e-73: 274: 17.86
+	Hs
		164568 APC_HUMAN (1-2843): 0: 1316: 100.00		SPTN2_HUMAN (35-303): 3.64e-64: 245: 17.95
+	Hs
		626291 APC_HUMAN (1-2843): 0: 1316: 100.00		MACF1_HUMAN (31-372): 2.07e-62: 240: 15.43
+	Hs
		598253 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		FLNA_HUMAN (56-1958): 3.04e-130: 461: 10.79
+	Hs
		598120 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		FLNA_HUMAN (56-1958): 3.04e-130: 461: 10.79
+	Hs
		598284 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		FLNA_HUMAN (56-1958): 3.04e-130: 461: 10.79
+	Hs
		261264 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		FLNB_HUMAN (66-1699): 2.33e-114: 410: 9.60
+	Hs
		725681 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN2_HUMAN (48-429): 2.39e-91: 321: 16.67
+	Hs
		993278 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN3_HUMAN (64-429): 6.88e-90: 317: 18.54
+	Hs
		521586 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN1_HUMAN (57-429): 8.72e-90: 316: 17.95
+	Hs
		211629 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN4_HUMAN (32-429): 6.45e-89: 314: 16.87
+	Hs
		1068702 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		PLEC_HUMAN (12-413): 1.01e-72: 274: 18.16
+	Hs
		963451 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		SPTB2_HUMAN (35-310): 4.94e-73: 274: 17.86
+	Hs
		521599 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		ACTN1_HUMAN (57-429): 8.72e-90: 316: 17.95
+	Hs
		1303336 MUC4_HUMAN (710-2820): 1.56e-75: 284: 9.45		MUC4_HUMAN (422-1925): 2.37e-18: 95.2: 12.40
+	Dm
		113976 M9PB30_DROME (1208-2013): 4.08e-21: 104: 9.83		M9PB30_DROME (1006-1784): 1.43e-19: 99.3: 9.02