HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 1024
+	Hs
		1041254 CUL1_HUMAN (6-745): 0: 775: 36.24		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1043285 CUL4A_HUMAN (4-745): 0: 773: 26.86		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1043636 CUL4B_HUMAN (4-745): 0: 771: 27.79		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1042791 CUL3_HUMAN (1-745): 0: 768: 26.38		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1274076 CUL5_HUMAN (7-745): 0: 627: 26.69		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		983120 CUL4A_HUMAN (4-745): 0: 773: 26.86		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		125440 CUL1_HUMAN (6-745): 0: 775: 36.24		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		808117 CUL1_HUMAN (6-745): 0: 775: 36.24		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		1042286 CUL3_HUMAN (1-745): 0: 768: 26.38		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808209 CUL5_HUMAN (7-745): 0: 627: 26.69		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04