HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17908926
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 499
+	Hs
		1041577 KMT2A_HUMAN (1-3969): 0: 3227: 100.00		FBXW7_HUMAN (72-332): 1.54e-42: 162: 14.44
+	Hs
		964869 KMT2A_HUMAN (1-3969): 0: 3227: 100.00		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		1041578 KMT2A_HUMAN (1-3969): 0: 3227: 100.00		SNR40_HUMAN (433-498): 5.15e-11: 66.1: 23.88
+	Hs
		1419379 SETD2_HUMAN (3398-3968): 9.76e-78: 291: 15.76		NLE1_HUMAN (167-499): 2.33e-87: 278: 19.27
+	At
		1421791 ATX1_ARATH (3430-3969): 1.49e-99: 351: 21.12		WDR5A_ARATH (297-497): 2.07e-53: 184: 19.12
+	Hs
		1155633 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		FBXW7_HUMAN (72-332): 1.54e-42: 162: 14.44
+	Hs
		984126 EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39		GBB2_HUMAN (296-497): 1.4e-34: 134: 21.74
+	Dm
		1208005 SET1_DROME (3423-3969): 7.78e-82: 303: 22.11		WDS_DROME (342-498): 1.4e-42: 156: 20.25
+	Hs
		216486 SUV91_HUMAN (3602-3968): 3.98e-87: 294: 18.39		DAW1_HUMAN (340-499): 2.2e-37: 143: 20.37
+	Hs
		965330 KMT2B_HUMAN (3525-3969): 1.17e-87: 324: 54.51		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		1387641 KMT2B_HUMAN (3525-3969): 1.17e-87: 324: 54.51		SNR40_HUMAN (433-498): 5.15e-11: 66.1: 23.88
+	Hs
		1387545 SETD2_HUMAN (3398-3968): 9.76e-78: 291: 15.76		SNR40_HUMAN (433-498): 5.15e-11: 66.1: 23.88
+	Sc
		805559 SET1_YEAST (3466-3969): 6.12e-72: 267: 22.10		CDH1_YEAST (315-495): 3.22e-17: 86.5: 12.57
+	Hs
		965335 SET1B_HUMAN (3529-3969): 8.08e-69: 261: 26.17		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		175868 SET1A_HUMAN (3695-3969): 7.81e-56: 219: 34.58		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		355576 NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23		SNR40_HUMAN (433-498): 5.15e-11: 66.1: 23.88
+	Hs
		1387546 NSD3_HUMAN (3750-3968): 4.91e-56: 219: 25.68		SNR40_HUMAN (433-498): 5.15e-11: 66.1: 23.88
+	Mm
		965395 KMT2C_MOUSE (1686-1977): 1.03e-11: 74.1: 15.54		WDR5_MOUSE (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		965097 KMT2C_HUMAN (1816-1977): 4.38e-11: 72.1: 24.10		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		161443 KMT2D_HUMAN (15-1365): 1.92e-09: 66.8: 9.31		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18