HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: CSN3 (Q9UNS2)
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)
Gene: COPS3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	33961781, 21145461, 26186194, 28514442, 16036220, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 423
+	Hs
		1041281 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1043308 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Mm
		56786 CUL4B_MOUSE (4-745): 0: 771: 27.79		CSN3_MOUSE (1-423): 9.97e-145: 420: 99.53
+	Hs
		1043639 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1042844 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		897243 CUL2_HUMAN (1-745): 0: 840: 100.00		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	At
		1228139 CUL4_ARATH (4-745): 0: 720: 26.60		CSN3_ARATH (3-423): 1.96e-117: 351: 38.00
+	Hs
		198618 CUL3_HUMAN (1-745): 0: 768: 26.38		PSMD3_HUMAN (49-415): 3.19e-93: 292: 18.14
+	At
		1258869 CUL3A_ARATH (3-745): 0: 788: 30.07		CSN2_ARATH (19-398): 6.77e-85: 267: 11.95
+	Hs
		897242 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Mm
		897343 CUL1_MOUSE (6-745): 0: 775: 36.24		CSN2_MOUSE (21-393): 1.28e-87: 275: 12.23
+	Hs
		1041454 CUL2_HUMAN (1-745): 0: 840: 100.00		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		897245 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897246 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897244 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	At
		1258866 CUL1_ARATH (3-745): 0: 727: 26.53		CSN2_ARATH (19-398): 6.77e-85: 267: 11.95
+	Hs
		1041179 CUL1_HUMAN (6-745): 0: 775: 36.24		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1043195 CUL4A_HUMAN (4-745): 0: 773: 26.86		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1043547 CUL4B_HUMAN (4-745): 0: 771: 27.79		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1042418 CUL3_HUMAN (1-745): 0: 768: 26.38		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87