HitPredict

Interactor 1: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Interactor 2: DDX24 (Q9GZR7)
ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)
Gene: DDX24

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	16169070
Identification Methods	two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEAD~DEAD, DEAD~Helicase_C, Helicase_C~Helicase_C
Common GO terms	GO:0003723 - RNA binding GO:0003724 - RNA helicase activity GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 859
+	Sc
		485732 IF4A_YEAST (24-407): 7e-167: 474: 65.89		DHH1_YEAST (287-742): 6.34e-140: 426: 24.57
+	Sc
		415868 IF4A_YEAST (24-407): 7e-167: 474: 65.89		DED1_YEAST (255-734): 7.5e-120: 377: 23.74
+	Hs
		133951 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Hs
		134146 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Hs
		133874 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Hs
		571538 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		DDX5_HUMAN (232-774): 1.14e-121: 382: 19.89
+	Hs
		571300 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		DDX5_HUMAN (232-774): 1.14e-121: 382: 19.89
+	Hs
		133911 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Sc
		624206 DBP1_YEAST (4-406): 3.09e-127: 382: 31.52		DBP1_YEAST (188-717): 3.88e-122: 384: 21.94
+	Sc
		624023 DBP2_YEAST (22-405): 1.21e-131: 390: 32.65		DBP2_YEAST (207-717): 8.32e-118: 370: 19.19
+	Sc
		415893 DBP1_YEAST (4-406): 3.09e-127: 382: 31.52		DED1_YEAST (255-734): 7.5e-120: 377: 23.74
+	Sc
		485721 IF4A_YEAST (24-407): 7e-167: 474: 65.89		DBP8_YEAST (388-708): 1.73e-34: 139: 31.31
+	Hs
		1271690 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		DDX41_HUMAN (390-691): 7.07e-32: 134: 31.17
+	Hs
		571626 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		DDX41_HUMAN (390-691): 7.07e-32: 134: 31.17
+	Hs
		757792 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		DDX41_HUMAN (390-691): 7.07e-32: 134: 31.17
+	Hs
		1271612 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		DDX17_HUMAN (130-267): 9.12e-12: 70.9: 21.43
+	Hs
		757701 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		DDX17_HUMAN (130-267): 9.12e-12: 70.9: 21.43