HitPredict

Interactor 1: GLI1 (P08151)
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
Gene: GLI1

Interactor 2: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	26603838, 22094256
Identification Methods	affinity chromatography technology, enzymatic study, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~zf-C2H2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1106 Hs			1 303
+	Hs
		414688 GLI1_HUMAN (1-1106): 0: 620: 100.00		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Hs
		960216 GLIS1_HUMAN (237-396): 4.47e-50: 190: 61.49		CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03
+	Hs
		515502 GLIS2_HUMAN (237-384): 4.86e-43: 167: 58.39		CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00
+	Dm
		618392 GLIS2_DROME (237-385): 1.27e-46: 174: 56.29		CDK1_DROME (3-297): 4.27e-125: 360: 39.33
+	Hs
		960243 GLIS2_HUMAN (237-384): 4.86e-43: 167: 58.39		CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03
+	Dm
		1178735 GLIS2_DROME (237-385): 1.27e-46: 174: 56.29		Q7K306_DROME (5-299): 6.28e-123: 356: 47.12
+	Dm
		618448 GLIS2_DROME (237-385): 1.27e-46: 174: 56.29		CDK2_DROME (6-295): 8.61e-69: 218: 43.88