HitPredict

Interactor 1: RHO1 (Q22038)
Ras-like GTP-binding protein rhoA
Gene: rho-1

Interactor 2: Q22354 (Q22354)
DH domain-containing protein
Gene: rhgf-2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	22363657
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Ce			1 862
+	Hs
		988820 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		PKHG1_HUMAN (75-861): 1.53e-124: 409: 14.11
+	Hs
		988408 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		PKHG6_HUMAN (18-662): 1.56e-95: 318: 21.36
+	Hs
		165458 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		RGRF2_HUMAN (80-770): 1.36e-85: 299: 12.60
+	Hs
		584511 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		VAV_HUMAN (41-621): 2.23e-86: 295: 14.94
+	Hs
		913637 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		VAV2_HUMAN (40-653): 4.2e-86: 295: 14.13
+	Hs
		988618 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		SPT13_HUMAN (97-577): 5.5e-86: 289: 13.73
+	Hs
		988587 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		ARHG2_HUMAN (31-643): 1.35e-82: 287: 16.84
+	Hs
		988741 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		ARHG4_HUMAN (101-559): 8.58e-84: 284: 13.73
+	Ce
		1041913 RAC1_CAEEL (1-192): 1.64e-79: 236: 55.96		VAV_CAEEL (35-727): 3.97e-81: 283: 13.21
+	Hs
		533818 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		MCF2_HUMAN (43-572): 5.71e-80: 279: 12.77
+	Hs
		988811 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		VAV3_HUMAN (41-598): 1.63e-80: 279: 14.39
+	Hs
		988716 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		ECT2_HUMAN (6-601): 8.61e-79: 275: 14.31
+	Hs
		238812 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		KALRN_HUMAN (120-810): 3.5e-65: 241: 11.86
+	Hs
		299534 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		TRIO_HUMAN (120-828): 2.1e-60: 226: 11.86
+	Hs
		177376 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		ARHGB_HUMAN (125-479): 3.88e-46: 181: 20.05
+	Sp
		1439782 RHO5_SCHPO (4-192): 5.93e-94: 273: 64.29		RGF1_SCHPO (96-491): 2e-23: 109: 18.98
+	Sp
		1068725 RHO1_SCHPO (1-192): 2.51e-84: 249: 66.34		RGF2_SCHPO (112-443): 9.88e-26: 116: 19.42
+	Sp
		1068728 RHO1_SCHPO (1-192): 2.51e-84: 249: 66.34		RGF1_SCHPO (96-491): 2e-23: 109: 18.98
+	Hs
		988526 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		NGEF_HUMAN (115-476): 1.44e-25: 115: 19.95
+	Hs
		988602 RAC1_HUMAN (1-192): 8.44e-80: 237: 58.76		ARHGQ_HUMAN (87-538): 2.76e-25: 114: 15.35