HitPredict

Interactor 1: FRAS1 (Q86XX4)
Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)
Gene: FRAS1

Interactor 2: KLK5 (Q9Y337)
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)
Gene: KLK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.630

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4008 Hs			1 293
+	Hs
		1294391 FRAS1_HUMAN (1-4008): 0: 2793: 100.00		KLK11_HUMAN (64-292): 1.94e-100: 297: 50.43
+	Hs
		455653 FRAS1_HUMAN (1-4008): 0: 2793: 100.00		KLK3_HUMAN (58-292): 1.88e-94: 281: 40.89
+	Hs
		1395507 PCD16_HUMAN (1185-3149): 0: 815: 9.93		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		1250386 PCD23_HUMAN (1258-2779): 0: 664: 10.31		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		1211504 FREM2_HUMAN (1229-3238): 1.69e-107: 390: 18.67		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		1047787 NOTC2_HUMAN (345-1137): 3.79e-51: 204: 12.46		KLK5_HUMAN (1-293): 3.05e-129: 370: 100.00
+	Hs
		1461972 NOTC3_HUMAN (355-1145): 4.51e-55: 217: 12.17		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		1047790 NOTC2_HUMAN (345-1137): 3.79e-51: 204: 12.46		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		437665 NOTC2_HUMAN (345-1137): 3.79e-51: 204: 12.46		HEPS_HUMAN (35-293): 5.05e-94: 285: 30.99
+	Hs
		1047609 NOTC2_HUMAN (345-1137): 3.79e-51: 204: 12.46		TM11B_HUMAN (54-288): 3.81e-93: 283: 31.30
+	Hs
		457979 AGRV1_HUMAN (2798-3348): 1.46e-17: 93.6: 15.69		TRY1_HUMAN (46-293): 1.08e-115: 334: 44.18
+	Hs
		449593 PCSK6_HUMAN (314-564): 5.18e-18: 94.2: 20.90		KLK1_HUMAN (50-293): 7.39e-99: 292: 37.35
+	Hs
		628390 PCSK6_HUMAN (314-564): 5.18e-18: 94.2: 20.90		KLK2_HUMAN (55-292): 9.7e-99: 292: 41.20
+	Hs
		1453627 CRIM1_HUMAN (473-1103): 2.28e-14: 82.2: 13.84		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		1369119 PCSK5_HUMAN (12-434): 3.79e-14: 82: 13.91		ST14_HUMAN (23-288): 4.81e-95: 300: 32.04
+	Hs
		709079 PCSK6_HUMAN (314-564): 5.18e-18: 94.2: 20.90		KLK15_HUMAN (70-292): 1.92e-96: 286: 42.31
+	Hs
		709081 PCSK6_HUMAN (314-564): 5.18e-18: 94.2: 20.90		TMPS4_HUMAN (27-291): 7.44e-94: 285: 27.37
+	Hs
		449623 CHRD_HUMAN (90-280): 6.31e-15: 84.3: 32.11		KLK1_HUMAN (50-293): 7.39e-99: 292: 37.35
+	Hs
		1432117 CELR2_HUMAN (4-196): 8.58e-10: 67.8: 12.09		KLK15_HUMAN (70-292): 1.92e-96: 286: 42.31
+	Mm
		405588 NOTC1_MOUSE (5-403): 1.89e-12: 76.6: 12.39		GRAB_MOUSE (60-292): 1.47e-38: 137: 34.73