Protein: FREM2
FRAS1-related extracellular matrix protein 2 (ECM3 homolog)

Gene: FREM2
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q5SZK8

Gene Ontology (top 5):
GO:0001654 - eye development
GO:0001822 - kidney development
GO:0002009 - morphogenesis of an epithelium
GO:0005604 - basement membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1211502

PSG8
Pregnancy-specific beta-1-glycoprotein 8

2

18

High-throughput

0.726

High

731856

CEAM8
Cell adhesion molecule CEACAM8

1

18

High-throughput

0.691

High

376398

PDGFB
Platelet-derived growth factor subunit B

2

6

High-throughput

0.628

High

553354

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

4

High-throughput

0.628

High

1211501

DKKL1
Dickkopf-like protein 1

2

13

High-throughput

0.628

High

1211507

PCDGD
Protocadherin gamma-B1

2

20

High-throughput

0.628

High

1204604

FREM1
FRAS1-related extracellular matrix protein 1

1

15

Small-scale

0.618

High

469797

CATG
Cathepsin G

2

20

High-throughput

0.611

High

761241

RYK
Tyrosine-protein kinase RYK

2

14

Small-scale

0.611

High

327006

NXPH2
Neurexophilin-2

3

13

High-throughput

0.609

High

70895

ZBBX
Zinc finger B-box domain-containing protein 1

2

4

High-throughput

0.574

High

351692

SG1D1
Secretoglobin family 1D member 1

2

4

High-throughput

0.574

High

1030785

DEF5
Defensin alpha 5

2

3

High-throughput

0.574

High

1211491

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

5

High-throughput

0.574

High

1211496

TAFA4
Chemokine-like protein TAFA-4

2

4

High-throughput

0.574

High

1211500

XAGE1
X antigen family member 1

2

9

High-throughput

0.549

High

169300

LECT2
Leukocyte cell-derived chemotaxin-2

1

3

High-throughput

0.536

High

480818

LEG1
Galectin-1

1

13

High-throughput

0.536

High

616082

LAG3
Lymphocyte activation gene 3 protein

1

4

High-throughput

0.536

High

663550

CMA1
Chymase

1

20

High-throughput

0.536

High

774772

TIMP3
Metalloproteinase inhibitor 3

1

2

High-throughput

0.536

High

859857

RL28
Large ribosomal subunit protein eL28

1

8

High-throughput

0.536

High

1211486

ATS17
A disintegrin and metalloproteinase with thrombospondin motifs 17

1

13

High-throughput

0.536

High

1211487

DCNP1
Dendritic cell nuclear protein 1

1

7

High-throughput

0.536

High

1211505

HYOU1
Hypoxia up-regulated protein 1

1

4

High-throughput

0.536

High

485191

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.515

High

1211497

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

66793

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

9

High-throughput

0.489

High

1090697

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.489

High

1211482

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

14

High-throughput

0.489

High

1211483

TAFA5
Chemokine-like protein TAFA-5

1

4

High-throughput

0.489

High

1211484

TAFA2
Chemokine-like protein TAFA-2

1

4

High-throughput

0.489

High

1211489

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

1

High-throughput

0.489

High

1211493

UCN3
Urocortin-3

1

4

High-throughput

0.489

High

1211503

RT17
Small ribosomal subunit protein uS17m

1

2

High-throughput

0.489

High

378115

TNFA
Tumor necrosis factor

1

2

High-throughput

0.479

High

861644

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.479

High

965715

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

High-throughput

0.479

High

1211488

LIPH
Lipase member H

1

3

High-throughput

0.479

High

1211495

CALR3
Calreticulin-3

1

4

High-throughput

0.479

High

688027

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

388416

B3AT
Band 3 anion transport protein

1

2

High-throughput

0.445

High

123116

DX39A
ATP-dependent RNA helicase DDX39A

1

4

High-throughput

0.437

High

951199

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

1160388

TAZ
Tafazzin

1

4

High-throughput

0.437

High

1211479

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.437

High

1211481

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1211485

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

2

High-throughput

0.437

High

1211490

DNS2B
Deoxyribonuclease-2-beta

1

4

High-throughput

0.437

High

1211498

CHST8
Carbohydrate sulfotransferase 8

1

1

High-throughput

0.437

High

1211499

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.437

High

1211504

KLK5
Kallikrein-5

1

13

High-throughput

0.437

High

1211494

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.426

High

667330

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.279

Low

1211480

TRI68
E3 ubiquitin-protein ligase TRIM68

1

0

High-throughput

0.279

Low

1211506

INSL6
Insulin-like peptide INSL6

1

0

High-throughput

0.279

Low

74513

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.269

Low

1211492

ARHG2
Rho guanine nucleotide exchange factor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025