Protein: PCSK6
Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)

Gene: PCSK6
Organism: Homo sapiens
Interactions: 59
UniProt ID: P29122

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

709075

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

20

High-throughput

0.783

High

168380

NCTR3
Natural cytotoxicity triggering receptor 3

1

5

High-throughput

0.691

High

709062

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.691

High

709063

FSTL4
Follistatin-related protein 4

1

20

High-throughput

0.691

High

709078

SIRPD
Signal-regulatory protein delta

1

2

High-throughput

0.691

High

709068

TMM25
Transmembrane protein 25

3

2

High-throughput

0.667

High

709076

LRC59
Leucine-rich repeat-containing protein 59

1

14

High-throughput

0.618

High

399433

TRGV3
T cell receptor gamma variable 3

1

3

High-throughput

0.575

High

73778

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

9

High-throughput

0.536

High

164762

GDF8
Growth/differentiation factor 8

1

9

High-throughput

0.536

High

231300

EFNA2
Ephrin-A2

1

6

High-throughput

0.536

High

316655

LY6H
Lymphocyte antigen 6H

1

1

High-throughput

0.536

High

342514

LY86
Lymphocyte antigen 86

1

5

High-throughput

0.536

High

388696

C1QB
Complement C1q subcomponent subunit B

1

10

High-throughput

0.536

High

426053

PPB1
Alkaline phosphatase, placental type

1

5

High-throughput

0.536

High

449593

KLK1
Kallikrein-1

1

18

High-throughput

0.536

High

506825

CFC1
Cryptic protein

1

6

High-throughput

0.536

High

567801

PRG2
Bone marrow proteoglycan

1

16

High-throughput

0.536

High

570650

EDN3
Endothelin-3

1

2

High-throughput

0.536

High

596962

TSHR
Thyrotropin receptor

1

9

High-throughput

0.536

High

597789

CRIS2
Cysteine-rich secretory protein 2

1

4

High-throughput

0.536

High

628390

KLK2
Kallikrein-2

1

18

High-throughput

0.536

High

635419

C4BPB
C4b-binding protein beta chain

1

5

High-throughput

0.536

High

709055

MFAP4
Microfibril-associated glycoprotein 4

1

7

High-throughput

0.536

High

709057

IL5RA
Interleukin-5 receptor subunit alpha

1

20

High-throughput

0.536

High

709064

BRID5
BRICHOS domain-containing protein 5

1

3

High-throughput

0.536

High

709065

LYZL1
Lysozyme-like protein 1

1

6

High-throughput

0.536

High

709069

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

5

High-throughput

0.536

High

709072

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

709073

FIBIN
Fin bud initiation factor homolog

1

2

High-throughput

0.536

High

709074

GGH
Gamma-glutamyl hydrolase

1

7

High-throughput

0.536

High

709077

ESPB1
Epididymal sperm-binding protein 1

1

8

High-throughput

0.536

High

709079

KLK15
Kallikrein-15

1

16

High-throughput

0.536

High

709080

SDF2L
Stromal cell-derived factor 2-like protein 1

1

8

High-throughput

0.536

High

709082

CBLN4
Cerebellin-4

1

9

High-throughput

0.536

High

709083

DNJB9
DnaJ homolog subfamily B member 9

1

20

High-throughput

0.536

High

640771

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

4

High-throughput

0.515

High

600598

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.513

High

709067

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.513

High

709084

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.513

High

139687

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

4

High-throughput

0.508

High

709061

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

13

High-throughput

0.494

High

647328

IDS
Iduronate 2-sulfatase

1

4

High-throughput

0.489

High

370157

CYTN
Cystatin-SN

1

2

Small-scale

0.479

High

400333

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

18

High-throughput

0.479

High

709053

BASI
Basigin

1

11

High-throughput

0.479

High

709056

VIGLN
Vigilin

1

1

High-throughput

0.479

High

709060

CUL3
Cullin-3

1

17

High-throughput

0.479

High

709066

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

709081

TMPS4
Transmembrane protease serine 4

1

13

High-throughput

0.479

High

332202

UCP5
Brain mitochondrial carrier protein 1

1

12

High-throughput

0.445

High

709054

EAA1
Excitatory amino acid transporter 1

1

4

High-throughput

0.445

High

709058

SLC31
Amino acid transporter heavy chain SLC3A1

1

4

High-throughput

0.445

High

709059

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

3

High-throughput

0.445

High

174486

TRI66
Tripartite motif-containing protein 66

1

11

High-throughput

0.437

High

293252

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

704504

RXRB
Retinoic acid receptor RXR-beta

1

10

High-throughput

0.437

High

709071

ZN441
Zinc finger protein 441

2

0

High-throughput

0.316

High

709070

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025