HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: ELNE (P08246)
Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
Gene: ELANE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	10867014, unassigned3799, 16321984
Identification Methods	pull down, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0002020 - protease binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005794 - Golgi apparatus GO:0043231 - intracellular membrane-bounded organelle and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 267
+	Hs
		369312 A1AT_HUMAN (1-418): 0: 525: 100.00		PRTN3_HUMAN (30-255): 7.04e-92: 273: 53.71
+	Hs
		369296 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK1_HUMAN (3-250): 1.76e-91: 272: 25.09
+	Mm
		459955 A1AT1_MOUSE (1-418): 1.99e-164: 469: 63.96		Q9Z1R9_MOUSE (8-249): 2.82e-105: 307: 32.41
+	Hs
		369427 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		ELNE_HUMAN (1-267): 2.38e-100: 295: 100.00
+	Hs
		369520 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		KLK13_HUMAN (32-261): 1.92e-96: 285: 27.76
+	Hs
		398000 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLKB1_HUMAN (13-256): 1.61e-97: 300: 26.24
+	Mm
		459951 A1AT1_MOUSE (1-418): 1.99e-164: 469: 63.96		ELNE_MOUSE (1-259): 2.59e-92: 275: 73.08
+	Hs
		397992 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		FA11_HUMAN (22-248): 1.2e-91: 284: 27.24
+	Hs
		369329 A1AT_HUMAN (1-418): 0: 525: 100.00		GRAM_HUMAN (13-249): 3.09e-34: 125: 33.46
+	Hs
		369301 A1AT_HUMAN (1-418): 0: 525: 100.00		CATG_HUMAN (25-247): 1.04e-33: 124: 36.71
+	Hs
		369299 A1AT_HUMAN (1-418): 0: 525: 100.00		CEL2A_HUMAN (28-246): 2.79e-32: 121: 34.57
+	Hs
		369297 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK3_HUMAN (26-246): 1.16e-27: 108: 32.51
+	Hs
		369417 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK4_HUMAN (28-249): 1.95e-25: 102: 30.90
+	Hs
		369447 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		GRAM_HUMAN (13-249): 3.09e-34: 125: 33.46
+	Hs
		369428 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		CATG_HUMAN (25-247): 1.04e-33: 124: 36.71
+	Mm
		459954 A1AT1_MOUSE (1-418): 1.99e-164: 469: 63.96		CELA1_MOUSE (28-246): 1.94e-34: 126: 36.78
+	Hs
		518736 SPB9_HUMAN (49-415): 1.01e-160: 458: 33.60		GRAB_HUMAN (25-248): 1.8e-34: 126: 34.87
+	Hs
		895476 SPB9_HUMAN (49-415): 1.01e-160: 458: 33.60		GRAM_HUMAN (13-249): 3.09e-34: 125: 33.46
+	Hs
		425160 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLK3_HUMAN (26-246): 1.16e-27: 108: 32.51
+	Hs
		469779 SPB4_HUMAN (48-415): 5.84e-150: 432: 32.31		CATG_HUMAN (25-247): 1.04e-33: 124: 36.71