HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	15494398
Identification Methods	comigration in sds page
Interaction Type	physical association, protein cleavage

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 257
+	Hs
		188770 A1AT_HUMAN (1-418): 0: 525: 100.00		TMPS2_HUMAN (10-257): 4.45e-99: 299: 26.26
+	Hs
		369299 A1AT_HUMAN (1-418): 0: 525: 100.00		CEL2A_HUMAN (5-256): 7.93e-99: 291: 32.84
+	Hs
		369447 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		GRAM_HUMAN (1-257): 2.16e-108: 315: 100.00
+	Mm
		459955 A1AT1_MOUSE (1-418): 1.99e-164: 469: 63.96		Q9Z1R9_MOUSE (1-256): 7.59e-109: 315: 31.15
+	Hs
		895476 SPB9_HUMAN (49-415): 1.01e-160: 458: 33.60		GRAM_HUMAN (1-257): 2.16e-108: 315: 100.00
+	Hs
		369520 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		KLK13_HUMAN (28-255): 1.5e-99: 293: 34.89
+	Hs
		398000 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLKB1_HUMAN (17-256): 2.91e-100: 307: 30.40
+	Hs
		1309633 SPA12_HUMAN (1-418): 2.21e-154: 444: 38.28		TM11E_HUMAN (25-255): 5.42e-100: 299: 29.66
+	Mm
		1000456 IPSP_MOUSE (52-415): 8.04e-150: 432: 42.23		TM11E_MOUSE (20-255): 7.89e-103: 307: 31.12
+	Hs
		457955 SPB8_HUMAN (48-415): 2.88e-146: 422: 31.48		TRY1_HUMAN (5-257): 1.81e-109: 317: 31.27
+	Hs
		895465 SPB8_HUMAN (48-415): 2.88e-146: 422: 31.48		TMPSD_HUMAN (11-253): 5.05e-100: 304: 29.08
+	Hs
		767094 SPB6_HUMAN (48-415): 3.96e-146: 421: 30.16		TM11A_HUMAN (1-255): 6.6e-99: 296: 27.69
+	Hs
		369417 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK4_HUMAN (8-256): 4.56e-38: 135: 36.36
+	Hs
		369312 A1AT_HUMAN (1-418): 0: 525: 100.00		PRTN3_HUMAN (25-255): 1.2e-33: 124: 37.24
+	Hs
		518736 SPB9_HUMAN (49-415): 1.01e-160: 458: 33.60		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		369437 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25
+	Hs
		425167 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25
+	Mm
		1221626 SPB6_MOUSE (48-415): 8.74e-149: 428: 30.42		KLK8_MOUSE (8-251): 2.54e-33: 123: 34.26
+	Hs
		664032 ILEU_HUMAN (49-415): 2.57e-146: 422: 29.92		PRTN3_HUMAN (25-255): 1.2e-33: 124: 37.24
+	Hs
		628392 SPB6_HUMAN (48-415): 3.96e-146: 421: 30.16		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25