HitPredict

Interactor 1: SPB9 (P50453)
Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)
Gene: SERPINB9

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	15494398
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Hs			1 257
+	Hs
		457955 SPB8_HUMAN (1-376): 1.15e-160: 456: 61.17		TRY1_HUMAN (5-257): 1.81e-109: 317: 31.27
+	Hs
		895465 SPB8_HUMAN (1-376): 1.15e-160: 456: 61.17		TMPSD_HUMAN (11-253): 5.05e-100: 304: 29.08
+	Hs
		767094 SPB6_HUMAN (1-376): 8.47e-159: 452: 62.80		TM11A_HUMAN (1-255): 6.6e-99: 296: 27.69
+	Hs
		767104 SPB6_HUMAN (1-376): 8.47e-159: 452: 62.80		KLK13_HUMAN (28-255): 1.5e-99: 293: 34.89
+	Hs
		369447 AACT_HUMAN (4-376): 1.93e-145: 420: 33.77		GRAM_HUMAN (1-257): 2.16e-108: 315: 100.00
+	Hs
		369329 A1AT_HUMAN (2-376): 3.56e-141: 409: 33.77		GRAM_HUMAN (1-257): 2.16e-108: 315: 100.00
+	Hs
		762249 SPB12_HUMAN (1-376): 2.04e-144: 416: 38.42		TRY3_HUMAN (12-257): 6.66e-105: 307: 32.80
+	Hs
		398000 IPSP_HUMAN (6-376): 9.18e-141: 407: 33.87		KLKB1_HUMAN (17-256): 2.91e-100: 307: 30.40
+	Hs
		369520 AACT_HUMAN (4-376): 1.93e-145: 420: 33.77		KLK13_HUMAN (28-255): 1.5e-99: 293: 34.89
+	Hs
		188770 A1AT_HUMAN (2-376): 3.56e-141: 409: 33.77		TMPS2_HUMAN (10-257): 4.45e-99: 299: 26.26
+	Hs
		369299 A1AT_HUMAN (2-376): 3.56e-141: 409: 33.77		CEL2A_HUMAN (5-256): 7.93e-99: 291: 32.84
+	Hs
		518736 SPB9_HUMAN (1-376): 3.08e-179: 504: 100.00		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		664032 ILEU_HUMAN (1-376): 3.62e-160: 455: 49.47		PRTN3_HUMAN (25-255): 1.2e-33: 124: 37.24
+	Hs
		628392 SPB6_HUMAN (1-376): 8.47e-159: 452: 62.80		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25
+	Mm
		1221626 SPB6_MOUSE (1-376): 1.53e-156: 446: 60.89		KLK8_MOUSE (8-251): 2.54e-33: 123: 34.26
+	Hs
		369240 ANT3_HUMAN (3-376): 4.03e-147: 426: 37.08		GRAA_HUMAN (25-249): 3.87e-39: 138: 37.50
+	Hs
		369417 A1AT_HUMAN (2-376): 3.56e-141: 409: 33.77		KLK4_HUMAN (8-256): 4.56e-38: 135: 36.36
+	Hs
		369437 AACT_HUMAN (4-376): 1.93e-145: 420: 33.77		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25
+	Hs
		369312 A1AT_HUMAN (2-376): 3.56e-141: 409: 33.77		PRTN3_HUMAN (25-255): 1.2e-33: 124: 37.24
+	Hs
		425167 IPSP_HUMAN (6-376): 9.18e-141: 407: 33.87		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25