HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: KLK1 (P06870)
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
Gene: KLK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	3643793
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 262
+	Hs
		369297 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK3_HUMAN (1-261): 3.99e-108: 314: 60.54
+	Hs
		369437 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90
+	Mm
		459955 A1AT1_MOUSE (1-418): 1.99e-164: 469: 63.96		Q9Z1R9_MOUSE (5-261): 2.6e-114: 329: 40.86
+	Hs
		369520 AACT_HUMAN (16-417): 5.91e-167: 476: 43.14		KLK13_HUMAN (1-260): 1.51e-105: 308: 40.07
+	Hs
		425167 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90
+	Hs
		369234 ANT3_HUMAN (17-418): 3.05e-143: 418: 28.40		KLK1_HUMAN (1-262): 3.96e-125: 357: 100.00
+	Hs
		449594 KAIN_HUMAN (49-417): 3.62e-140: 408: 45.62		KLK1_HUMAN (1-262): 3.96e-125: 357: 100.00
+	Hs
		425160 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLK3_HUMAN (1-261): 3.99e-108: 314: 60.54
+	Hs
		628392 SPB6_HUMAN (48-415): 3.96e-146: 421: 30.16		KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90
+	Hs
		457955 SPB8_HUMAN (48-415): 2.88e-146: 422: 31.48		TRY1_HUMAN (5-262): 3.07e-114: 329: 40.31
+	Hs
		767104 SPB6_HUMAN (48-415): 3.96e-146: 421: 30.16		KLK13_HUMAN (1-260): 1.51e-105: 308: 40.07
+	Mm
		1221626 SPB6_MOUSE (48-415): 8.74e-149: 428: 30.42		KLK8_MOUSE (2-260): 1.88e-102: 300: 42.86
+	Hs
		398000 IPSP_HUMAN (26-415): 6.22e-156: 448: 43.83		KLKB1_HUMAN (22-261): 3.78e-90: 280: 32.55
+	Hs
		895465 SPB8_HUMAN (48-415): 2.88e-146: 422: 31.48		TMPSD_HUMAN (8-258): 2.88e-89: 277: 30.08
+	Hs
		369417 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK4_HUMAN (23-258): 1.1e-50: 168: 40.08
+	Hs
		210637 A1AT_HUMAN (1-418): 0: 525: 100.00		KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29
+	Hs
		210686 CBG_HUMAN (50-415): 5.75e-153: 440: 43.99		KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29
+	Hs
		518736 SPB9_HUMAN (49-415): 1.01e-160: 458: 33.60		GRAB_HUMAN (25-258): 4.02e-37: 132: 36.52
+	Hs
		210726 SPB10_HUMAN (48-415): 3e-148: 428: 30.56		KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29
+	Hs
		369240 ANT3_HUMAN (17-418): 3.05e-143: 418: 28.40		GRAA_HUMAN (24-258): 3.09e-37: 133: 35.92