HitPredict

Interactor 1: KLK2 (P20151)
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Gene: KLK2

Interactor 2: SPB6 (P35237)
Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)
Gene: SERPINB6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	26186194, 11745444
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 376
+	Hs
		767104 KLK13_HUMAN (1-259): 4.31e-108: 315: 44.65		SPB6_HUMAN (1-376): 2.35e-171: 484: 100.00
+	Hs
		457955 TRY1_HUMAN (2-260): 2.19e-119: 342: 42.09		SPB8_HUMAN (1-376): 1.57e-159: 454: 66.40
+	Mm
		1221626 KLK8_MOUSE (4-257): 2.05e-105: 307: 44.88		SPB6_MOUSE (1-376): 1.85e-162: 461: 75.99
+	Hs
		369234 KLK1_HUMAN (1-260): 5.95e-118: 339: 65.90		ANT3_HUMAN (4-376): 1.42e-148: 429: 36.91
+	Hs
		369437 KLK2_HUMAN (1-261): 8.68e-122: 349: 100.00		AACT_HUMAN (4-376): 1.26e-143: 415: 33.68
+	Mm
		459955 Q9Z1R9_MOUSE (2-260): 4.87e-119: 341: 41.70		A1AT1_MOUSE (4-376): 3.56e-142: 411: 32.36
+	Hs
		425167 KLK2_HUMAN (1-261): 8.68e-122: 349: 100.00		IPSP_HUMAN (6-376): 6.97e-138: 400: 32.00
+	Hs
		762249 TRY3_HUMAN (11-260): 1.25e-112: 327: 42.80		SPB12_HUMAN (1-376): 5.65e-146: 421: 41.24
+	Hs
		369296 KLK1_HUMAN (1-260): 5.95e-118: 339: 65.90		A1AT_HUMAN (2-376): 8.26e-141: 408: 32.01
+	Hs
		895465 TMPSD_HUMAN (8-257): 3e-94: 290: 31.30		SPB8_HUMAN (1-376): 1.57e-159: 454: 66.40
+	Hs
		369297 KLK3_HUMAN (1-261): 8.04e-115: 331: 77.01		A1AT_HUMAN (2-376): 8.26e-141: 408: 32.01
+	Hs
		425160 KLK3_HUMAN (1-261): 8.04e-115: 331: 77.01		IPSP_HUMAN (6-376): 6.97e-138: 400: 32.00
+	Hs
		369520 KLK13_HUMAN (1-259): 4.31e-108: 315: 44.65		AACT_HUMAN (4-376): 1.26e-143: 415: 33.68
+	Hs
		369299 CEL2A_HUMAN (5-260): 1.76e-93: 277: 33.09		A1AT_HUMAN (2-376): 8.26e-141: 408: 32.01
+	Hs
		210726 KLK10_HUMAN (28-260): 7.2e-45: 154: 39.49		SPB10_HUMAN (1-376): 1.61e-160: 457: 44.84
+	Hs
		369417 KLK4_HUMAN (23-260): 4.7e-52: 171: 40.17		A1AT_HUMAN (2-376): 8.26e-141: 408: 32.01
+	Hs
		210637 KLK10_HUMAN (28-260): 7.2e-45: 154: 39.49		A1AT_HUMAN (2-376): 8.26e-141: 408: 32.01
+	Hs
		210686 KLK10_HUMAN (28-260): 7.2e-45: 154: 39.49		CBG_HUMAN (4-376): 6e-135: 393: 34.31
+	Hs
		450170 KLK2_HUMAN (1-261): 8.68e-122: 349: 100.00		GDN_HUMAN (26-376): 2.24e-58: 196: 32.12
+	Hs
		450191 KLK13_HUMAN (1-259): 4.31e-108: 315: 44.65		GDN_HUMAN (26-376): 2.24e-58: 196: 32.12