HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: TRX (P20659)
Histone-lysine N-methyltransferase trithorax (EC 2.1.1.355) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Lysine N-methyltransferase 2A)
Gene: TRX

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.911

Property	Details
Experiments	12408863, 24235145, 24550119, 14730313, unassigned4
Identification Methods	enzymatic study, experimental interaction detection
Interaction Type	direct interaction, methylation reaction, physical association

Property	Details
Interacting Pfam domains	Histone~PHD, Histone~SET
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 3726
+	Hs
		998234 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2A_HUMAN (2715-3726): 4.67e-88: 326: 24.24
+	Hs
		1041540 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		KMT2A_HUMAN (2715-3726): 4.67e-88: 326: 24.24
+	Hs
		998359 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		EZH2_HUMAN (3103-3709): 1.79e-91: 318: 14.41
+	Hs
		1155419 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		EZH2_HUMAN (3103-3709): 1.79e-91: 318: 14.41
+	Hs
		998715 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		RSF1_HUMAN (868-1391): 5.66e-85: 312: 14.36
+	Hs
		998773 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD3_HUMAN (914-1869): 1.21e-82: 304: 12.00
+	Hs
		998772 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SETD2_HUMAN (3089-3725): 4.05e-81: 302: 15.23
+	Hs
		998942 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2B_HUMAN (2781-3726): 3.7e-80: 299: 23.82
+	Hs
		175872 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SET1A_HUMAN (2710-3726): 3.96e-75: 281: 15.58
+	Hs
		273420 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KDM4A_HUMAN (1531-2006): 1.61e-76: 281: 12.86
+	Hs
		273432 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		KDM4A_HUMAN (1531-2006): 1.61e-76: 281: 12.86
+	Hs
		998807 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SUV92_HUMAN (3405-3726): 5.31e-77: 265: 19.42
+	Hs
		216410 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SUV91_HUMAN (3399-3725): 3.91e-75: 259: 19.39
+	Hs
		998948 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SET1B_HUMAN (3506-3726): 4.38e-62: 239: 33.47
+	Hs
		161446 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2D_HUMAN (1099-1490): 1.45e-22: 110: 15.18
+	Hs
		998565 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2C_HUMAN (883-1406): 1.5e-22: 109: 12.19
+	Hs
		998694 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD1_HUMAN (3590-3725): 7.12e-17: 90.9: 39.13
+	Hs
		355489 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD2_HUMAN (973-1485): 8.82e-16: 87.3: 14.46
+	Hs
		355534 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		NSD2_HUMAN (973-1485): 8.82e-16: 87.3: 14.46
+	Hs
		998846 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		ASH1L_HUMAN (2795-3552): 7.47e-10: 67.8: 11.03