HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: ATX3 (P54252)
Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)
Gene: ATXN3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.992

Property	Details
Experiments	23659897, 28190767, 29576527, 38803224, 16196087, 23314748, 25231079, 25144244, 21118805, 12857950, 18599482, 25988170, 25527291, 25448680, 28918024, 29661116, 30455355, 16020535, 16118278, 16040601 and 6 others more... 20622874, 20865150, 14602712, 23625928, 14559776, 19153604
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Josephin~ubiquitin, UIM~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 361
+	Hs
		476365 UBC_HUMAN (1-685): 0: 846: 100.00		ATX3L_HUMAN (1-361): 2.05e-156: 445: 69.81
+	Hs
		475787 UBC_HUMAN (1-685): 0: 846: 100.00		JOS1_HUMAN (4-169): 2.79e-54: 179: 25.28
+	Hs
		476081 UBC_HUMAN (1-685): 0: 846: 100.00		JOS2_HUMAN (3-165): 3.15e-53: 175: 23.46
+	Hs
		474967 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		ATX3_HUMAN (1-361): 0: 508: 100.00
+	Mm
		476980 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ATX3_MOUSE (1-361): 4.44e-173: 487: 85.08