HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 35575683, unassigned1304
Identification Methods	two hybrid, cross-linking study, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 590
+	Hs
		475506 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10
+	Hs
		475532 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K22E_HUMAN (140-484): 3.02e-174: 509: 71.88
+	Hs
		437062 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23
+	Hs
		475501 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C7_HUMAN (74-494): 9.72e-163: 474: 65.09
+	Hs
		341726 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02
+	Hs
		475621 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C73_HUMAN (1-589): 1.61e-101: 319: 51.27
+	Hs
		475559 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT83_HUMAN (70-550): 1.82e-92: 294: 47.10
+	Hs
		475576 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT81_HUMAN (55-567): 4.72e-92: 294: 46.50
+	Hs
		407240 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6B_HUMAN (2-505): 1.51e-89: 289: 79.56
+	Hs
		475560 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT85_HUMAN (1-483): 3.06e-90: 289: 50.31
+	Hs
		475542 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6C_HUMAN (2-505): 3.09e-89: 288: 79.17
+	Hs
		227200 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT86_HUMAN (70-483): 7.62e-89: 285: 52.66
+	Hs
		475588 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C71_HUMAN (1-558): 3.89e-87: 281: 51.79
+	Hs
		385220 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6A_HUMAN (2-505): 1.61e-85: 278: 79.17
+	Hs
		475598 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C79_HUMAN (55-499): 5.64e-85: 276: 65.55
+	Hs
		475579 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C72_HUMAN (1-546): 1.01e-81: 267: 53.66
+	Hs
		475613 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C74_HUMAN (1-557): 8.66e-81: 265: 52.78
+	Hs
		475516 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C4_HUMAN (11-500): 8.4e-77: 254: 66.12
+	Hs
		475561 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K22O_HUMAN (1-496): 2.12e-73: 248: 62.74
+	Hs
		475615 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C1B_HUMAN (36-499): 3.72e-72: 244: 60.35