HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: KRT85 (P78386)
Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)
Gene: KRT85

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 507
+	Hs
		475501 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C7_HUMAN (14-445): 2.24e-160: 465: 53.46
+	Hs
		475506 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C3_HUMAN (95-434): 2.74e-128: 388: 58.14
+	Hs
		407363 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C1_HUMAN (92-448): 8.41e-123: 375: 54.44
+	Hs
		437062 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C8_HUMAN (46-461): 7.45e-114: 346: 53.61
+	Hs
		475701 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT84_HUMAN (1-506): 1.42e-106: 332: 56.55
+	Hs
		475559 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT83_HUMAN (1-500): 2.11e-105: 325: 80.44
+	Hs
		475576 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT81_HUMAN (16-489): 2.22e-103: 320: 83.37
+	Hs
		227200 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT86_HUMAN (7-498): 5.41e-102: 316: 81.17
+	Hs
		475621 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C73_HUMAN (3-503): 1.58e-91: 291: 43.43
+	Hs
		341726 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C75_HUMAN (3-437): 1.12e-87: 281: 49.78
+	Hs
		475702 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT82_HUMAN (1-506): 9.86e-87: 277: 59.25
+	Hs
		475588 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C71_HUMAN (3-505): 2.93e-82: 266: 42.16
+	Hs
		475598 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C79_HUMAN (13-454): 7.94e-82: 265: 45.56
+	Hs
		475579 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C72_HUMAN (10-507): 3.07e-80: 260: 43.45
+	Hs
		475510 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C5_HUMAN (3-437): 2.79e-74: 247: 48.65
+	Hs
		407240 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6B_HUMAN (1-437): 1.97e-73: 244: 49.69
+	Hs
		475542 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6C_HUMAN (1-437): 4.68e-73: 243: 49.69
+	Hs
		475613 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C74_HUMAN (59-506): 9.91e-73: 241: 45.78
+	Hs
		385220 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6A_HUMAN (90-437): 8.41e-72: 240: 60.00
+	Hs
		475516 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C4_HUMAN (6-453): 1.46e-69: 233: 47.22