HitPredict

Interactor 1: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Interactor 2: K2C71 (Q3SY84)
Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)
Gene: KRT71

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 35575683, unassigned1304
Identification Methods	two hybrid, cross-linking study, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 523
+	Hs
		407363 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C1_HUMAN (95-460): 3.16e-160: 471: 67.21
+	Hs
		475615 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C1B_HUMAN (43-458): 1.01e-160: 470: 58.05
+	Hs
		475532 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K22E_HUMAN (102-447): 4.36e-154: 456: 68.21
+	Hs
		475501 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C7_HUMAN (62-457): 5.66e-136: 403: 60.10
+	Hs
		437062 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C8_HUMAN (102-466): 3.31e-135: 402: 61.14
+	Hs
		475621 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C73_HUMAN (1-523): 1.14e-111: 343: 77.96
+	Hs
		341726 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C75_HUMAN (1-457): 1.23e-95: 302: 57.56
+	Hs
		475560 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT85_HUMAN (3-501): 1.4e-95: 301: 44.47
+	Hs
		475576 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT81_HUMAN (3-445): 1.65e-93: 295: 48.53
+	Hs
		475598 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C79_HUMAN (14-521): 5.03e-93: 295: 53.92
+	Hs
		475559 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT83_HUMAN (4-458): 3.18e-93: 294: 46.81
+	Hs
		227200 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		KRT86_HUMAN (3-445): 5e-92: 291: 48.53
+	Hs
		475579 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C72_HUMAN (1-523): 4.81e-87: 279: 70.29
+	Hs
		407240 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6B_HUMAN (2-502): 7.35e-83: 269: 55.16
+	Hs
		475510 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C5_HUMAN (1-453): 1.25e-82: 269: 56.01
+	Hs
		475542 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6C_HUMAN (2-462): 1.18e-82: 269: 57.20
+	Hs
		475613 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C74_HUMAN (1-523): 2.67e-83: 269: 69.85
+	Hs
		385220 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C6A_HUMAN (2-462): 4.24e-79: 259: 57.40
+	Hs
		475516 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K2C4_HUMAN (12-461): 1.94e-75: 249: 62.09
+	Hs
		475561 K1C19_HUMAN (1-400): 2.56e-156: 448: 100.00		K22O_HUMAN (1-458): 5.34e-70: 237: 57.14