HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	30664872, 28190767, 33141564
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 908
+	Hs
		476252 UBC_HUMAN (1-685): 0: 846: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		923974 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		397947 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Mm
		476933 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PSMD2_MOUSE (1-908): 0: 1273: 98.68
+	At
		1092336 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD2A_ARATH (11-906): 0: 1080: 49.51
+	At
		1091720 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD2B_ARATH (11-906): 0: 1073: 49.62
+	Ce
		477558 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q9GZH5_CAEEL (37-906): 0: 1023: 47.53
+	Sc
		477264 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RPN1_YEAST (49-906): 0: 869: 37.71
+	Sp
		251843 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		RPN2_SCHPO (59-844): 0: 667: 16.61
+	At
		221381 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD1A_ARATH (59-841): 0: 791: 17.60
+	At
		1092259 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD1B_ARATH (59-841): 0: 785: 18.30
+	Sc
		477186 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RPN2_YEAST (59-841): 0: 679: 17.83
+	Hs
		924124 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Mm
		476785 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PSMD1_MOUSE (59-845): 0: 788: 16.61
+	Rn
		292216 UBC_RAT (1-108): 1.27e-29: 127: 90.74		PSMD1_RAT (59-845): 0: 784: 17.42
+	Hs
		398072 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PSMD1_HUMAN (59-845): 0: 790: 17.31