HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	35235311, 38334954, 32814053
Identification Methods	cross-linking study, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 858
+	Hs
		507656 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP5_HUMAN (1-858): 0: 847: 100.00
+	Hs
		508376 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP13_HUMAN (2-858): 0: 727: 59.70
+	Hs
		508843 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP22_HUMAN (139-667): 2.43e-112: 355: 13.24
+	Hs
		508377 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		USP9X_HUMAN (289-795): 1.16e-86: 305: 14.26
+	Hs
		508652 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP42_HUMAN (270-809): 1.69e-86: 302: 12.46
+	Hs
		508751 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP36_HUMAN (251-817): 3.49e-86: 299: 14.12
+	Hs
		138905 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		USP9Y_HUMAN (289-795): 1.28e-83: 296: 14.44
+	Hs
		507299 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UBP7_HUMAN (247-777): 1e-83: 292: 13.54
+	Hs
		508156 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		U17L2_HUMAN (259-798): 6.6e-90: 296: 11.79
+	Hs
		508378 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP7_HUMAN (247-777): 1e-83: 292: 13.54
+	Hs
		67123 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP27_HUMAN (262-667): 3.82e-86: 283: 14.96
+	Hs
		288434 Q5U5U6_HUMAN (1-229): 2.65e-99: 289: 100.00		UBP2_HUMAN (281-660): 3.14e-79: 269: 14.18
+	Hs
		288338 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP2_HUMAN (281-660): 3.14e-79: 269: 14.18
+	Hs
		275867 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP12_HUMAN (306-681): 2.03e-81: 268: 14.67
+	Hs
		507144 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UBP46_HUMAN (292-681): 5.47e-80: 264: 13.71
+	Hs
		507772 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP46_HUMAN (292-681): 5.47e-80: 264: 13.71
+	Hs
		507635 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP8_HUMAN (283-649): 3.57e-69: 250: 17.92
+	Hs
		508807 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP21_HUMAN (319-594): 1.47e-25: 114: 19.64
+	Hs
		508328 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP33_HUMAN (174-455): 1.14e-24: 113: 22.18
+	Hs
		508925 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBP3_HUMAN (801-853): 1.15e-10: 66.9: 36.36