Protein: DOCK1
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)

Gene: DOCK1
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q14185

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1050484

ELMO1
Engulfment and cell motility protein 1

15

20

Small-scale

0.983

High

802596

CRK
Adapter molecule crk

13

20

Small-scale

0.980

High

924565

GRB2
Growth factor receptor-bound protein 2

8

20

Small-scale

0.968

High

925276

RAC1
Ras-related C3 botulinum toxin substrate 1

6

20

Small-scale

0.935

High

1050494

DOCK5
Dedicator of cytokinesis protein 5

3

13

High-throughput

0.852

High

1050476

ANR54
Ankyrin repeat domain-containing protein 54

3

9

High-throughput

0.839

High

545372

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

High-throughput

0.811

High

802842

CRKL
Crk-like protein

2

20

High-throughput

0.811

High

1050487

ELMO3
Engulfment and cell motility protein 3

2

20

High-throughput

0.811

High

950991

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.789

High

522979

SRC
Proto-oncogene tyrosine-protein kinase Src

2

12

Small-scale

0.754

High

1050474

DOCK1
Dedicator of cytokinesis protein 1

2

12

Small-scale

0.754

High

209053

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.740

High

1050492

DOCK9
Dedicator of cytokinesis protein 9

2

13

High-throughput

0.737

High

882289

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

13

Small-scale

0.724

High

1050490

CYH2
Cytohesin-2

1

0

Small-scale

0.687

High

1050482

GRASP
Protein TAMALIN

2

7

Small-scale

0.634

High

1050499

FBW1A
F-box/WD repeat-containing protein 1A

3

6

High-throughput

0.633

High

166926

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

7

Small-scale

0.618

High

350167

RASK
GTPase KRas

1

20

High-throughput

0.618

High

384825

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.618

High

412190

FYN
Tyrosine-protein kinase Fyn

1

12

High-throughput

0.618

High

551048

CHIN
N-chimaerin

1

8

High-throughput

0.618

High

557689

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

915674

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

983610

FAK1
Focal adhesion kinase 1

1

15

Small-scale

0.618

High

1050483

ICEF1
Interactor protein for cytohesin exchange factors 1

1

12

Small-scale

0.618

High

1050489

ELMO2
Engulfment and cell motility protein 2

1

20

High-throughput

0.618

High

1050495

ANFY1
Rabankyrin-5

1

7

High-throughput

0.618

High

430177

PROF1
Profilin-1

2

7

Small-scale

0.584

High

1050497

FBW1B
F-box/WD repeat-containing protein 11

2

5

High-throughput

0.584

High

173711

SURF4
Surfeit locus protein 4

2

1

High-throughput

0.571

High

229949

NUAK1
NUAK family SNF1-like kinase 1

1

13

High-throughput

0.536

High

274219

STK16
Serine/threonine-protein kinase 16

1

14

High-throughput

0.536

High

362200

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

713092

SDC2
Syndecan-2

1

2

High-throughput

0.536

High

984262

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

2

High-throughput

0.536

High

1039552

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1040977

CUL1
Cullin-1

1

9

High-throughput

0.536

High

1050477

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

1050486

SPSB4
SPRY domain-containing SOCS box protein 4

1

19

High-throughput

0.536

High

1050491

INP5K
Inositol polyphosphate 5-phosphatase K

1

2

High-throughput

0.536

High

1050493

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

5

High-throughput

0.536

High

568661

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

Small-scale

0.501

High

1050498

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

10

High-throughput

0.489

High

776220

ARL4A
ADP-ribosylation factor-like protein 4A

1

14

Small-scale

0.479

High

1035431

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.479

High

1050475

CEBPE
CCAAT/enhancer-binding protein epsilon

1

3

Small-scale

0.479

High

1050479

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1050485

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1050488

SPDLY
Protein Spindly

1

9

High-throughput

0.479

High

1050496

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1050478

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

1050480

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1050481

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024