Protein: HES4
Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4)

Gene: HES4
Organism: Homo sapiens
Interactions: 35
UniProt ID: Q9HCC6

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890683

RGS3
Regulator of G-protein signaling 3

1

0

High-throughput

0.537

High

713459

SPB3
Serpin B3

1

4

High-throughput

0.536

High

1047867

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.536

High

844002

HD
Huntingtin

1

2

High-throughput

0.515

High

1096230

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.515

High

1438827

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

961643

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.494

High

1430243

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

1

High-throughput

0.494

High

791739

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

1025145

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

261659

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

276631

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

485819

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

839626

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.489

High

895468

SPB8
Serpin B8

1

4

High-throughput

0.489

High

1309620

SPA12
Serpin A12

1

6

High-throughput

0.489

High

468823

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

1212036

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.479

High

1031958

NC2B
Protein Dr1

1

1

High-throughput

0.470

High

157875

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

1438825

RAB21
Ras-related protein Rab-21

1

1

High-throughput

0.437

High

317928

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.292

High

1438824

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.292

High

652414

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

939535

FCGRN
IgG receptor FcRn large subunit p51

1

0

High-throughput

0.279

Low

1213838

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

1338069

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.279

Low

1400652

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

1404712

PAFA2
Platelet-activating factor acetylhydrolase 2, cytoplasmic

1

0

High-throughput

0.279

Low

1438826

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

244186

KIF5C
Kinesin heavy chain isoform 5C

1

0

High-throughput

0.249

Low

665495

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.249

Low

1197152

AT134
Probable cation-transporting ATPase 13A4

1

0

High-throughput

0.249

Low

1395232

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

1

0

High-throughput

0.249

Low

1410213

CMS1
Protein CMSS1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025