HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 807
+	Hs
		618245 CADH2_HUMAN (1-906): 0: 911: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		618220 CADH2_HUMAN (1-906): 0: 911: 100.00		PTN6_HUMAN (2-344): 6.75e-137: 420: 32.30
+	Hs
		618215 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRB_HUMAN (18-314): 1.71e-117: 394: 31.19
+	Rn
		1225811 CADH2_RAT (1-906): 0: 905: 96.25		PTPRF_RAT (6-292): 3.5e-102: 349: 36.43
+	Hs
		614647 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRA_HUMAN (20-290): 3.18e-104: 340: 37.59
+	Gg
		148792 CADH2_CHICK (1-906): 0: 886: 85.20		PTN1_CHICK (22-288): 8.66e-118: 364: 34.88
+	Hs
		618254 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRK_HUMAN (20-292): 9.37e-61: 225: 30.96
+	Rn
		98591 CADH2_RAT (1-906): 0: 905: 96.25		F1LPJ1_RAT (20-293): 1.38e-61: 228: 29.08
+	Hs
		618216 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRG_HUMAN (30-294): 2.94e-51: 196: 25.54
+	Hs
		618248 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRJ_HUMAN (15-295): 2.83e-48: 187: 38.10
+	Hs
		555875 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRD_HUMAN (13-292): 2.68e-106: 361: 36.36
+	Hs
		556057 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRS_HUMAN (13-292): 1.55e-105: 359: 35.66
+	Hs
		618257 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRO_HUMAN (45-299): 3.58e-43: 171: 38.22
+	Hs
		522579 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRF_HUMAN (6-292): 1.79e-101: 347: 36.77
+	Hs
		658884 DSC3_HUMAN (5-899): 0: 699: 30.32		PTPRD_HUMAN (13-292): 2.68e-106: 361: 36.36
+	Hs
		471719 CADH2_HUMAN (1-906): 0: 911: 100.00		PTPRC_HUMAN (61-462): 3.97e-11: 69: 9.28
+	Hs
		555891 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRM_HUMAN (20-293): 2.67e-61: 227: 28.72
+	Mm
		486811 CADH1_MOUSE (2-906): 0: 728: 45.02		PTPRM_MOUSE (20-293): 1.19e-61: 228: 29.08
+	Hs
		555876 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRG_HUMAN (30-294): 2.94e-51: 196: 25.54
+	Hs
		556048 CADH1_HUMAN (26-906): 0: 734: 45.43		PTPRJ_HUMAN (15-295): 2.83e-48: 187: 38.10