HitPredict

Interactor 1: TRY3 (P35030)
Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV)
Gene: PRSS3

Interactor 2: SPB12 (Q96P63)
Serpin B12
Gene: SERPINB12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 405
+	Hs
		457955 TRY1_HUMAN (69-304): 4.61e-126: 361: 86.02		SPB8_HUMAN (1-405): 1.05e-151: 435: 39.51
+	Mm
		459955 Q9Z1R9_MOUSE (65-303): 9.12e-127: 362: 76.99		A1AT1_MOUSE (4-405): 4.84e-135: 394: 30.03
+	Hs
		366283 FA10_HUMAN (15-302): 8.74e-106: 318: 31.43		SPB8_HUMAN (1-405): 1.05e-151: 435: 39.51
+	Hs
		628392 KLK2_HUMAN (65-303): 1.53e-102: 302: 42.46		SPB6_HUMAN (1-405): 1.22e-151: 435: 41.24
+	Hs
		767104 KLK13_HUMAN (83-302): 3.61e-102: 302: 44.93		SPB6_HUMAN (1-405): 1.22e-151: 435: 41.24
+	Hs
		366273 FA10_HUMAN (15-302): 8.74e-106: 318: 31.43		ANT3_HUMAN (4-405): 1.49e-139: 408: 34.64
+	Mm
		1221626 KLK8_MOUSE (77-300): 1.82e-97: 289: 41.92		SPB6_MOUSE (1-405): 1.46e-151: 435: 39.51
+	Hs
		369234 KLK1_HUMAN (62-304): 5.81e-102: 300: 42.02		ANT3_HUMAN (4-405): 1.49e-139: 408: 34.64
+	Hs
		369437 KLK2_HUMAN (65-303): 1.53e-102: 302: 42.46		AACT_HUMAN (4-405): 1.08e-137: 401: 29.14
+	Hs
		369520 KLK13_HUMAN (83-302): 3.61e-102: 302: 44.93		AACT_HUMAN (4-405): 1.08e-137: 401: 29.14
+	Hs
		366239 FA9_HUMAN (75-299): 1.59e-95: 291: 41.00		ANT3_HUMAN (4-405): 1.49e-139: 408: 34.64
+	Hs
		369296 KLK1_HUMAN (62-304): 5.81e-102: 300: 42.02		A1AT_HUMAN (2-405): 1.93e-136: 398: 28.71
+	Hs
		398000 KLKB1_HUMAN (5-303): 6.93e-99: 305: 30.16		IPSP_HUMAN (6-405): 8.31e-133: 388: 29.18
+	Hs
		369297 KLK3_HUMAN (79-303): 1.62e-98: 292: 42.02		A1AT_HUMAN (2-405): 1.93e-136: 398: 28.71
+	Hs
		425167 KLK2_HUMAN (65-303): 1.53e-102: 302: 42.46		IPSP_HUMAN (6-405): 8.31e-133: 388: 29.18
+	Hs
		402466 PROC_HUMAN (37-301): 6.85e-98: 297: 32.17		IPSP_HUMAN (6-405): 8.31e-133: 388: 29.18
+	Hs
		425160 KLK3_HUMAN (79-303): 1.62e-98: 292: 42.02		IPSP_HUMAN (6-405): 8.31e-133: 388: 29.18
+	Hs
		210726 KLK10_HUMAN (46-303): 2.7e-51: 172: 36.67		SPB10_HUMAN (1-405): 1.22e-161: 461: 41.24
+	Hs
		210637 KLK10_HUMAN (46-303): 2.7e-51: 172: 36.67		A1AT_HUMAN (2-405): 1.93e-136: 398: 28.71
+	Hs
		210686 KLK10_HUMAN (46-303): 2.7e-51: 172: 36.67		CBG_HUMAN (4-405): 1.89e-129: 380: 26.87