HitPredict

Interactor 1: ARL4A (P40617)
ADP-ribosylation factor-like protein 4A
Gene: ARL4A

Interactor 2: CYH2 (Q99418)
Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
Gene: CYTH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	17804820
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Arf~PH, Arf~Sec7
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 400
+	Hs
		975195 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Rn
		975369 ARF6_RAT (8-184): 3.76e-85: 250: 43.50		CYH2_RAT (1-400): 1.24e-179: 507: 99.25
+	Mm
		975367 ARF6_MOUSE (8-184): 3.76e-85: 250: 43.50		CYH1_MOUSE (2-397): 7.74e-177: 500: 82.58
+	Hs
		886308 ARL4D_HUMAN (1-200): 9.76e-81: 240: 60.20		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Hs
		975048 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		CYH1_HUMAN (2-397): 7.69e-176: 497: 83.08
+	Hs
		1014948 ARF1_HUMAN (1-190): 2.02e-67: 206: 41.58		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Hs
		975090 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		IQEC1_HUMAN (27-396): 5.41e-109: 343: 26.20
+	Hs
		975133 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		PSD4_HUMAN (1-389): 3.26e-107: 340: 21.95
+	Hs
		975352 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		BIG1_HUMAN (3-268): 5.7e-97: 319: 37.13
+	Dm
		829711 ARF6_DROME (8-184): 2.72e-83: 245: 44.07		Q6U9V3_DROME (61-366): 9.95e-98: 317: 30.36
+	Hs
		1015142 ARF5_HUMAN (9-189): 2.98e-87: 256: 42.54		PSD3_HUMAN (91-389): 8.33e-92: 299: 22.69
+	Hs
		975280 ARF6_HUMAN (8-184): 3.76e-85: 250: 43.50		PSD3_HUMAN (91-389): 8.33e-92: 299: 22.69
+	Sc
		536127 ARF1_YEAST (9-189): 5.7e-87: 255: 40.88		GEA2_YEAST (9-364): 2.03e-88: 293: 24.54
+	Sc
		535967 ARF1_YEAST (9-189): 5.7e-87: 255: 40.88		SEC7_YEAST (9-249): 2.66e-86: 288: 38.62
+	Dm
		958896 ARF1_DROME (1-191): 5.23e-67: 205: 41.89		Q9VJW1_DROME (5-285): 1.15e-90: 300: 35.66
+	Sc
		376306 YPT1_YEAST (21-200): 7.89e-66: 202: 24.31		GEA2_YEAST (9-364): 2.03e-88: 293: 24.54
+	Sc
		376261 YPT1_YEAST (21-200): 7.89e-66: 202: 24.31		SEC7_YEAST (9-249): 2.66e-86: 288: 38.62
+	Dm
		54748 O18332_DROME (21-199): 2.43e-67: 206: 23.89		A1Z8W9_DROME (49-271): 2.24e-80: 271: 33.33
+	Dm
		54753 ARF1_DROME (1-191): 5.23e-67: 205: 41.89		A1Z8W9_DROME (49-271): 2.24e-80: 271: 33.33
+	Hs
		631380 RAB5A_HUMAN (1-200): 7.17e-66: 203: 19.40		GBF1_HUMAN (51-257): 3.19e-80: 270: 37.26