HitPredict

Interactor 1: ARL4D (P49703)
ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L)
Gene: ARL4D

Interactor 2: CYH2 (Q99418)
Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
Gene: CYTH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	17804820
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Arf~PH, Arf~Sec7
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 201 Hs			1 400
+	Hs
		975195 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Rn
		975369 ARF6_RAT (14-185): 7.6e-79: 234: 40.12		CYH2_RAT (1-400): 1.24e-179: 507: 99.25
+	Mm
		975367 ARF6_MOUSE (14-185): 7.6e-79: 234: 40.12		CYH1_MOUSE (2-397): 7.74e-177: 500: 82.58
+	Hs
		975048 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		CYH1_HUMAN (2-397): 7.69e-176: 497: 83.08
+	Hs
		827304 ARL4A_HUMAN (1-201): 1.79e-71: 216: 60.20		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Hs
		1014948 ARF1_HUMAN (5-191): 4.4e-67: 205: 39.04		CYH2_HUMAN (1-400): 3e-180: 508: 100.00
+	Hs
		975090 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		IQEC1_HUMAN (27-396): 5.41e-109: 343: 26.20
+	Hs
		975133 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		PSD4_HUMAN (1-389): 3.26e-107: 340: 21.95
+	Hs
		975352 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		BIG1_HUMAN (3-268): 5.7e-97: 319: 37.13
+	Hs
		1015142 ARF5_HUMAN (8-190): 1.34e-81: 242: 39.79		PSD3_HUMAN (91-389): 8.33e-92: 299: 22.69
+	Sc
		536127 ARF1_YEAST (9-190): 4.55e-81: 240: 37.91		GEA2_YEAST (9-364): 2.03e-88: 293: 24.54
+	Hs
		975280 ARF6_HUMAN (14-185): 7.6e-79: 234: 40.12		PSD3_HUMAN (91-389): 8.33e-92: 299: 22.69
+	Sc
		535967 ARF1_YEAST (9-190): 4.55e-81: 240: 37.91		SEC7_YEAST (9-249): 2.66e-86: 288: 38.62
+	Dm
		958896 ARF1_DROME (5-192): 3.1e-67: 205: 37.77		Q9VJW1_DROME (5-285): 1.15e-90: 300: 35.66
+	Hs
		976703 RB11A_HUMAN (14-200): 1.43e-64: 199: 21.81		BIG2_HUMAN (3-268): 9.97e-91: 301: 36.40
+	Hs
		976611 RB11A_HUMAN (14-200): 1.43e-64: 199: 21.81		PSD3_HUMAN (91-389): 8.33e-92: 299: 22.69
+	Dm
		54753 ARF1_DROME (5-192): 3.1e-67: 205: 37.77		A1Z8W9_DROME (49-271): 2.24e-80: 271: 33.33
+	Dm
		54748 O18332_DROME (12-197): 5.18e-66: 203: 24.47		A1Z8W9_DROME (49-271): 2.24e-80: 271: 33.33
+	Hs
		631380 RAB5A_HUMAN (1-201): 6.46e-66: 203: 18.81		GBF1_HUMAN (51-257): 3.19e-80: 270: 37.26
+	Hs
		976457 RB11A_HUMAN (14-200): 1.43e-64: 199: 21.81		GBF1_HUMAN (51-257): 3.19e-80: 270: 37.26