HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: ARG28 (Q8N1W1)
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Gene: ARHGEF28

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19637314
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1705
+	Hs
		988587 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG2_HUMAN (627-1525): 1.6e-105: 364: 36.50
+	Sp
		1439782 RHO5_SCHPO (4-181): 2.58e-87: 256: 67.98		RGF1_SCHPO (349-1199): 1.15e-79: 292: 13.24
+	Sp
		1068728 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF1_SCHPO (349-1199): 1.15e-79: 292: 13.24
+	Mm
		694458 RHOA_MOUSE (1-196): 1.77e-78: 234: 83.16		RGRF1_MOUSE (625-1418): 1.12e-80: 294: 13.94
+	Hs
		988408 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PKHG6_HUMAN (718-1470): 7.46e-81: 286: 16.62
+	Hs
		988820 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PKHG1_HUMAN (741-1451): 1.16e-75: 279: 13.35
+	Hs
		165458 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		RGRF2_HUMAN (626-1621): 7.54e-75: 276: 12.77
+	Hs
		913637 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV2_HUMAN (747-1463): 2.86e-76: 275: 11.60
+	Hs
		988741 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHG4_HUMAN (576-1275): 6.01e-78: 275: 13.78
+	Hs
		165456 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		RGRF2_HUMAN (626-1621): 7.54e-75: 276: 12.77
+	Hs
		177376 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		ARHGB_HUMAN (482-1384): 6.09e-73: 272: 17.10
+	Hs
		177373 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		ARHGB_HUMAN (482-1384): 6.09e-73: 272: 17.10
+	Hs
		988618 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		SPT13_HUMAN (665-1221): 1.87e-75: 267: 12.72
+	Sp
		1068725 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		RGF2_SCHPO (461-1150): 1.23e-69: 259: 13.27
+	Hs
		539995 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		BCR_HUMAN (401-1297): 9.26e-70: 260: 12.60
+	Sc
		448555 RHO1_YEAST (3-186): 1.42e-88: 260: 67.39		ROM2_YEAST (819-1138): 2.09e-52: 205: 22.75
+	Hs
		238812 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		KALRN_HUMAN (792-1575): 8.07e-42: 171: 11.79
+	Hs
		584511 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		VAV_HUMAN (794-1194): 3.5e-41: 167: 19.51
+	Hs
		299534 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		TRIO_HUMAN (828-1429): 5.48e-38: 159: 11.40
+	Hs
		299530 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		TRIO_HUMAN (828-1429): 5.48e-38: 159: 11.40